Three 3D models with negative compressibility have been presented in our previous paper [X. Q. Zhou et al., Phys. Status Solidi B 2016, 253, 1977]. However, the 2D mechanism (i.e., wine‐rack mechanism) which we used to design 3D models is so symmetrical that the axial properties of it are equivalent, so we have only focused on geometry features. In this work, an extended study is conducted in order to find a more efficient method to design 3D structures with evident negative compressibility. Through theoretical modeling, the compressibility properties of three 3D models made from hinging hexagonal truss mechanism are analyzed and the conditions for negative compressibility to be exhibited are discussed. The study shows that in addition to the geometry features, negative compressibility effects can also be significantly affected by the arrangement of the framework and layout orientations of 2D mechanism.