Modelling low energy electron interactions for biomedical uses of radiation

Fuß, Martina; Muñoz, Antonio; Oller, J.C.; Blanco, F.; Limão-Vieira, P.; Huerga, C.; Téllez, M.; Hubin-Fraskin, M.J.; Nixon, Kate; Brunger, M. J.; Garcı́a, Gustavo

doi:10.1088/1742-6596/194/1/012028

Cited by 14 publications

(13 citation statements)

References 33 publications

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“…There has also been great interest in studying radiation damage in biological systems using Monte Carlo based track structure codes to describe the nature of damage resulting from high-energy incident radiation [6][7][8][9][10]. Cross-section data are essential to these simulations.…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical study of the triple-differential cross section for electron-impact ionization of thymine molecules

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Experimental and theoretical study of the triple-differential cross section for electron-impact ionization of thymine molecules

et al. 2012

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“…This can be done by calculating the path along which the primary and secondary particles move as they pass through matter, known as their charged particle track structures. [3][4][5][6] Detailed information is required on the initial spatial distribution of events involving both ionization and excitation along the charged particles path. Differential cross sections are an important source of this information as they enable a complete three-dimensional description of the deposition of energy as a function of angle.…”

Section: Introductionmentioning

confidence: 99%

“…Differential cross sections are an important source of this information as they enable a complete three-dimensional description of the deposition of energy as a function of angle. 5 In the majority of track structure simulations in biological media, the focus is on water 3,6 as the primary species in the system, but the inclusion of contributions from other species present is needed for a more complete description of the process. Due to the challenging nature of performing measurements and calculations of cross-sectional data for electron interactions with larger molecules, there are currently limited data for targets of biological interest.…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical investigation of the triple differential cross section for electron impact ionization of pyrimidine molecules

Builth-Williams

Bellm

Jones

et al. 2012

The Journal of Chemical Physics

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Cross-section data for electron impact induced ionization of bio-molecules are important for modelling the deposition of energy within a biological medium and for gaining knowledge of electron driven processes at the molecular level. Triply differential cross sections have been measured for the electron impact ionization of the outer valence 7b2 and 10a1 orbitals of pyrimidine, using the (e, 2e) technique. The measurements have been performed with coplanar asymmetric kinematics, at an incident electron energy of 250 eV and ejected electron energy of 20 eV, for scattered electron angles of −5°, −10°, and −15°. The ejected electron angular range encompasses both the binary and recoil peaks in the triple differential cross section. Corresponding theoretical calculations have been performed using the molecular 3-body distorted wave model and are in reasonably good agreement with the present experiment.

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“…9 These studies are particularly useful in attempting to achieve good therapeutic outcomes, where irradiated areas are reduced with the absorbed dose in surrounding healthy tissue minimized. For the particular case of DNA-damage, this requires a capacity for spatial resolutions of the order of a nanometre or better.…”

Section: Introductionmentioning

confidence: 99%

“…For the particular case of DNA-damage, this requires a capacity for spatial resolutions of the order of a nanometre or better. 9 Such a level of description in turn requires a detailed knowledge of the atomic and molecular properties of the target for the simulation.…”

Section: Introductionmentioning

confidence: 99%

Excitation of electronic states in tetrahydrofuran by electron impact

Thao

Leung

Fuß

et al. 2011

The Journal of Chemical Physics

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We report on differential and integral cross section measurements for the electron impact excitation of the three lowest lying Rydberg bands of electronic states in tetrahydrofuran. The energy range of the present experiments was 15-50 eV with the angular range of the differential cross section measurements being 15• -90• . The important effects of the long-range target dipole moment and the target dipole polarizability, on the scattering dynamics of this system, are evident from the present results. To the best of our knowledge, there are no other theoretical or experimental data against which we can compare the cross section results from this study.

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Modelling low energy electron interactions for biomedical uses of radiation

Cited by 14 publications

References 33 publications

Experimental and theoretical study of the triple-differential cross section for electron-impact ionization of thymine molecules

Experimental and theoretical study of the triple-differential cross section for electron-impact ionization of thymine molecules

Experimental and theoretical investigation of the triple differential cross section for electron impact ionization of pyrimidine molecules

Excitation of electronic states in tetrahydrofuran by electron impact

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