Modelling low energy electron and positron tracks in biologically relevant media

Blanco, F.; Muñoz, Antonio; Almeida, Diogo; Silva, F. Ferreira da; Limão-Vieira, P.; Fuß, Martina; Sanz, A.; Garcı́a, Gustavo

doi:10.1140/epjd/e2013-40276-1

Cited by 84 publications

(83 citation statements)

References 82 publications

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“…The LEPTS code has been described in detail elsewhere 36 and so only a brief description is given here. Briefly, the programme is based on critically selected experimental and theoretical input data previously compiled for each target molecule, in this particular case for water and pyrimidine.…”

Section: Lepts Programmementioning

confidence: 99%

“…While tracking an incident particle throughout the energy deposition process, elastic collisions and different types of inelastic interactions are distinguished and modelled according to the underlying input data. As such, for each collisional event, the programme samples the scattering angle and the particle's energy loss specifically according to the corresponding distribution functions, 36 which are the differential cross section (DCS) data and the energy loss spectra. The programme is also capable of providing an efficient response if an ionisation event takes place.…”

Section: Lepts Programmementioning

confidence: 99%

See 1 more Smart Citation

The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue: A comparative study

Fuß

Ellis-Gibbings

Jones

et al. 2015

Journal of Applied Physics

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Water is often used as the medium for characterizing the effects of radiation on living tissue. However, in this study, charged-particle track simulations are employed to quantify the induced physicochemical and potential biological implications when a primary ionising particle with energy 10 keV strikes a medium made up entirely of water or pyrimidine. Note that pyrimidine was chosen as the DNA/RNA bases cytosine, thymine, and uracil can be considered pyrimidine derivatives. This study aims to assess the influence of the choice of medium on the charged-particle transport, and identify how appropriate it is to use water as the default medium to describe the effects of ionising radiation on living tissue. Based on the respective electron interaction cross sections, we provide a model, which allows the study of radiation effects not only in terms of energy deposition (absorbed dose and stopping power) but also in terms of the number of induced molecular processes. Results of these parameters for water and pyrimidine are presented and compared.

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Section: Lepts Programmementioning

confidence: 99%

Section: Lepts Programmementioning

confidence: 99%

The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue: A comparative study

Fuß

Ellis-Gibbings

Jones

et al. 2015

Journal of Applied Physics

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“…Force spectroscopy is relatively insensitive to local substrate irregularities, since measurements are taken over an area determined by the diameter of the tip (i.e.,30-50 nm). Furthermore, for the experimental determination of LEE CSs at higher energies (i.e., 500 eV -10 keV), DNA film thicknesses must be in the range of 50 nm to few microns to account for the longer electron penetration distances (or lower total scattering CSs [29]). In this case, force spectroscopy, which has virtually no upper limit for thickness measurement, provides a significant advantage.…”

Section: Resultsmentioning

confidence: 99%

Absolute cross section for DNA damage induced by low-energy (10 eV) electrons: Experimental refinements and sample characterization by AFM

Brodeur

Cloutier

Bass

et al. 2018

The Journal of Chemical Physics

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This work describes multiple experimental improvements for measuring absolute cross sections of DNA damage induced by low-energy electrons (LEE) in nanometer-thick films in vacuum. Measurements of such cross sections are particularly sensitive to film thickness and uniformity. Using atomic force microscopy (AFM) in 70% ethanol, we present a novel and effective method to determine plasmid DNA film thickness and uniformity that combines height histograms and force-distance curves. We also investigate film deposition with DNA intercalated with 1,3-diaminopropane (Dap) on tantalum-coated substrates as a convenient and cost-effective alternative to the previously-used graphite substrate. The tantalum substrate permits deposition of films very similar to those formed on graphite. Using these refinements and further optimizations of the experimental procedure, we measure an absolute cross section of (4.7 ± 1.5) x10-14 cm 2 for conformational damage to a 3197 base-pair plasmid induced by 10 eV electrons, which we believe should be considered as a reference value. I. INTRODUCTION: Ionizing radiation is widely employed in cancer therapy (e.g., in radiotherapy [1, 2], brachytherapy [3] and targeted radionuclide therapy (TRT) [4,5]), as well as in medical diagnostic imaging. In these applications, the radiation dose given to the patient should be known and controlled. In conventional cancer treatments, calculations of the absorbed dose rely on scattering cross sections (CSs) of the primary high-energy radiation. In more sophisticated treatments, such as therapies combining radiation

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“…In recent years there have been many studies on positron stopping power and its applications. [5][6][7][8] We obtained, in a previous study 9 the SP formula for intermediate energy electrons, by using the generalized oscillator strength (GOS) model. Stopping power Calculations for positrons have not been studied as much, though their tracks in matter are frequently assumed to be similar to those of electrons.…”

Section: Introductionmentioning

confidence: 99%

Positron stopping power in some biological compounds for intermediate energies with generalized oscillator strength model

Gümüş¹,

Namdar²,

Bentabet³

2018

IJMBOA

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In this study total inelastic differential cross section and related stopping power expressions for positron were obtained by using generalized oscillator strength model. The stopping powers of low atomic number targets and of some biological compounds for positrons were calculated over the energy range from 50 eV to 10 MeV. Calculations of the stopping powers (SPs) for some low atomic number targets: H 2 , C, N 2 , O 2, P and for biological compounds: C 5 H 5 N 5 (adenine), C 5 H 5 N 5 O (guanine), C 5 H 5 N 3 O (cytosine), C 5 H 6 N 2 O 2 (thymine), C 20 H 27 N 7 O 13 P 2 (cytosine-guanine), and C 19 H 26 N 8 O 13 P 2 (thymine-adenine), have been evaluated for incident positrons in the 50 eV-10 MeV energy range. A detailed comparison of the calculated results with the other theoretical and experimental data for these target materials were presented. The calculated results of stopping powers for positrons in energy range from 50 eV to 10 MeV were found to be in good agreement to within 5% above 100 eV energies with other theoretical results.

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Modelling low energy electron and positron tracks in biologically relevant media

Cited by 84 publications

References 82 publications

The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue: A comparative study

The role of pyrimidine and water as underlying molecular constituents for describing radiation damage in living tissue: A comparative study

Absolute cross section for DNA damage induced by low-energy (10 eV) electrons: Experimental refinements and sample characterization by AFM

Positron stopping power in some biological compounds for intermediate energies with generalized oscillator strength model

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