Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK

Appleton, J.D.; Cave, Mark; Wragg, Joanna

doi:10.1016/j.envpol.2012.06.018

Cited by 53 publications

(17 citation statements)

References 32 publications

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“…The higher pH and increased concentration of a number of enzymes used to simulate intestinal phase of bioaccessibility tests leads to the complexation and precipitation of Pb from solution (Grøn and Andersen, 2003), resulting in lower bioaccessibility values and poorer reproducibility of results . In a similar manner to Appleton et al, (2012) the bioaccessibility values from the stomach phase of the PBET have been chosen for all data interpretation, as this phase is considered to provide a more conservative estimate of risk (Farmer et al, 2011). Lead bioaccessibility has been reported as an actual bioaccessible concentration (mg/kg) and as a fraction of the total Pb concentration in the sample (%) and referred to as the bioaccessible fraction (BAF).…”

Section: Bioaccessible Pb Concentrationsmentioning

confidence: 99%

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Palumbo-Roe

Wragg

Cave

et al. 2013

Environ Sci Pollut Res

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General assessments of orebody types and associated mine wastes with regards to their environmental signature and human health hazards are needed to help managing present and historical mine waste facilities.Bioaccessibility tests and mineralogical analysis were carried out on mine waste from a systematic sampling of mine sites from the Central Wales orefield, UK.The bioaccessible Pb widely ranged from 270 to 20300 mg/kg (mean 7250 mg/kg; median 4890 mg/kg) and the bioaccessible fraction from 4.53 % to >100 % (mean 33.2 %; median 32.2 %), with significant (p=0.001) differences among the mine sites. This implies sensitivity of bioaccessibility to site-specific conditions and suggests caution in the use of models to assess human health impacts generalised on the basis of the mineral deposit type. Mineralogical similarities of the oxidation products of primary galena provided a better control over the observed Pb bioaccessibility range. The higher Pb bioaccessibility (%) was related to samples containing cerussite, irrespective of the presence of other Pb minerals in the mineral assemblage; lower Pb bioaccessibility resulted where anglesite was the main Pb mineral phase and cerussite was absent.

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Section: Bioaccessible Pb Concentrationsmentioning

confidence: 99%

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Palumbo-Roe

Wragg

Cave

et al. 2013

Environ Sci Pollut Res

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“…Strong linear relationships were observed between bioaccessible Pb (both gastric and intestinal phases) and total Pb concentrations (Figure 3.1), which was in accordance with previous studies (Roussel et al, 2010;Appleton et al, 2012;Reis et al, 2014 (Appleton et al, 2012). Also, the variation associated with intestinal data (shown as error bar in Figure 3.1) was more pronounced than that of gastric data, which was probably due to wider range of pH (5.8-6.5) in the intestinal phase or inhomogeneity and complexation of intestinal solutions (Wragg et al, 2011).…”

Section: Relationships Between Pb Bioaccessibility Total Pb Concentrsupporting

confidence: 80%

“…There are a number of in vitro bioaccessibility testing systems available, among which the Unified BARGE Method (UBM) has been well established and commonly used as a screening tool (Appleton et al, 2012;Barsby et al, 2012). So far the results of UBM have been correlated with bioavailability data of a juvenile swine model (a good representative physiological condition of children) for As, Cd and Pb .…”

Section: Introductionmentioning

confidence: 99%

Assessing exposure risk of arsenic, cadmium and lead (or mixed with PAHs) in soils using in-vitro methods

Xia¹

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There are over 150,000 contaminated sites in Australia. In most cases, soils are polluted with mixtures of contaminants, including metal/metalloids. However, current human health assessment, particularly in relation to health investigation level guidelines is based on single contaminant. If no site-specific data are available, additive effect is assumed which may overestimate or underestimate the risk. Therefore, a more detailed study on the mixture of metal/metalloids is needed. The emphasis of this study is laid on the exposure risk of arsenic (As), cadmium (Cd), and lead (Pb) when they are ingested as mixtures. Two in-vitro models are adopted in this study. Model 1 is the Unified BARGE (Bioaccessibility Research Group of Europe) method (which is known as UBM) with the aim to measure the soluble fraction of soil contaminants in the human gastrointestinal tract (bioaccessibility) as well as the interaction effects of As, Cd and Pb on respective bioaccessibility. Model 2 is using human liver carcinoma cell line (HepG2) to study the subsequent uptake of contaminants into cells in target organ and possible interaction of As, Cd and Pb on their respective uptake after they are solubilised in the human digestive system. Considering at some contaminated sites polycyclic aromatic hydrocarbons (PAHs) may co-exist with As, Cd and Pb, effects of four selected PAHs (NAP for naphthalene, PHE for phenanthrene, PYR for pyrene, and B[a]P for benzo[a]pyrene) on the bioaccessibility and subsequent uptake of As, Cd and Pb into HepG2 cells are also preliminarily investigated. The focus of this PhD study is on mixtures of As, Cd and Pb.Seven chemically-variant top soils (0-20 cm) were collected in Australia. Soils were characterised for pH, total carbon, total nitrogen, total sulphur, total organic carbon, total inorganic carbon, cation exchange capacity, oxalate-extractable iron, aluminium and manganese, particle size distribution, electrical conductivity etc. A range of concentrations of As, Cd and Pb was spiked into these seven types of soils and aged for up to 12 months. UBM results show the bioaccessibility of As in the gastric phase was not significantly different from those in the intestinal phase whilst a pronounced difference was observed between Cd gastric bioaccessibility and intestinal bioaccessibility as well as between Pb gastric bioaccessibility and intestinal bioaccessibility. Organic carbon, iron oxide and aluminium oxide were key parameters influencing the bioaccessibility of As (gastric and intestinal phases), Cd (intestinal phase) and Pb (intestinal phase).For mixture studies, two exposure scenarios were investigated. Under the first scenario, As, Cd and Pb were spiked to individual soils to mimic independent ageing of mixed 3 contaminants, such as contaminants age at different spots or there has been a long time gap between different contaminants entering the same spot. The interaction between binary mixtures of As, Cd and Pb in simulated human digestive system was studied by mixing soils spiked with A...

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“…Regression analysis, Analysis of Covariance and bootstrap resampling was carried out following the methodology described in Appleton et al (2012). In the Rookhope area, a subset with <10,000 mg kg -1 total Pb was used for MLR, after removing a sample with a large leverage (27,203 mg kg -1 Pb).…”

Section: Discussionmentioning

confidence: 99%

“…described how soil pH, organic matter content, mineral constituents, and solid phase partitioning of PHEs and soil ageing may influence bioaccessibility of contaminants. Pb bioaccessibility studies have generally focussed on the relationships between total and bioaccessible Pb concentrations (Farmer et al, 2011;Cave et al, 2011;Appleton et al, 2012), sometimes with due consideration given to the different sources of Pb contamination (Smith et al 2011a), mineralogy and soil chemistry (Denys et al, 2007). There are a number of studies which illustrate that the bioaccessible fraction can come from different physico-chemical components in the soil.…”

Section: Introductionmentioning

confidence: 99%

Lead bioaccessibility in topsoils from lead mineralisation and urban domains, UK

Appleton

Cave

Palumbo-Roe

et al. 2013

Environmental Pollution

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Predictive linear regression (LR) modelling indicates that total Pb is the only highly significant independent variable for estimating Pb bioaccessibility in "mineralisation domains" located in limestone (high pH) and partly peat covered (low pH) shalesandstone terrains in England. Manganese is a significant minor predictor in the limestone terrain, whilst organic matter and sulphur explain 0.5% and 2% of the variance of bioaccessible Pb in the peat-shale-sandstone terrain, compared with 93% explained by total Pb. Bootstrap resampling shows that LR confidence limits overlap for the two mineralised terrains but the limestone terrain has a significantly lower bioaccessible Pb to total Pb slope than the urban domain. A comparison of the absolute values of stomach and combined stomach-intestine bioaccessibility provides some insight into the geochemical controls on bioaccessibility in the contrasting soil types. Capsule AbstractTotal Pb is the major predictor for bioaccessible Pb in topsoils from two lead mineralised areas in England.

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Modelling lead bioaccessibility in urban topsoils based on data from Glasgow, London, Northampton and Swansea, UK

Cited by 53 publications

References 32 publications

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Assessing exposure risk of arsenic, cadmium and lead (or mixed with PAHs) in soils using in-vitro methods

Lead bioaccessibility in topsoils from lead mineralisation and urban domains, UK

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