This thesis analyses the impact of firm-level frictions on adjustment mechanisms. It consists of three empirical studies that are based on a large and detailed data set of Swiss firms.These data enable the studies to account for the fact that firms are highly heterogeneous and that some firms are more exposed to frictions than others.The first essay analyses the response of firms' markups following an exchange rate shock.The adjustment of markups towards a new optimum proves to differs strongly across firms.Large firms vary their markup substantially, especially if they are also highly profitable or export intensive. In contrast, firms with low profitability, low productivity, low markups as well as small and domestic-oriented firms do not adjust their markups significantly following a change in the exchange rate. The second essay, co-authored with Gregor Bäurle and Sarah M. Lein, estimates firms' employment adjustment to changes in output. The results show that for firms in financially strained situations, the sensitivity of employment to fluctuations in output increases considerably. When output changes, financially tighter firms resize their labour force more than firms that have abundant funding. This implies that such firms drive the fluctuations of employment over the cycle. The third essay, also co-authored with Gregor Bäurle and Sarah M. Lein, estimates the sensitivity of the cost of external finance to firms' net worth. The results show that firms' cost of external finance and firms' net worth are inversely related. This is consistent with models that integrate financial frictions by means of a financial accelerator. Based on the estimated sensitivity, a range for the monitoring cost is derived. The monitoring cost is the cost, which financial intermediaries have to pay to be able to observe firms' realized return on capital. The estimated range is consistent with an economically significant financial friction. The results of these three essays provide micro-data evidence that frictions can substantially hamper the transmission of shocks and that the response differs strongly across firms.