Abstract:One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models that accurately mimic the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside catecholaminergic neurons. Neurons reaching the highest neuromelanin levels preferentially degenerate in Parkinson's, Alzheimer's and apparently healthy aging individuals. However, this brain pigment is not taken into consideration in current animal models because, in contrast… Show more
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