Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation

Patterson, A.; Ferreira, Ana P.; Banks, Elizabeth; Skeene, Kirsty; Clarke, Graham S.; Nicholson, Sarah J.; Rawlinson-Malone, Clare Frances

doi:10.1016/j.ijpharm.2014.11.063

Cited by 13 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patterson et al monitored the stability of dispersions of HPMC-AS for 6 months using HPLC (Patterson et al, 2015). Although the data reflected the impact of temperature and RH levels, it was clear that these terms alone did not account for all of the variability in the data.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs

Davis

Walker

2018

Journal of Controlled Release

125

View full text Add to dashboard Cite

Poorly water-soluble drugs are a significant and ongoing issue for the pharmaceutical industry. An overview of recent developments for the preparation of spray-dried delivery systems is presented. Examples include amorphous solid dispersions, spray dried dispersions, microparticles, nanoparticles, surfactant systems and self-emulsifying drug delivery systems. Several aspects of formulation are considered, such as pre-screening, choosing excipient(s), the effect of polymer structure on performance, formulation optimisation, ternary dispersions, fixed-dose combinations, solvent selection and component miscibility. Process optimisation techniques including nozzle selection are discussed. Comparisons are drawn with other preparation techniques such as hot melt extrusion, freeze drying, milling, electro spinning and film casting. Novel analytical and dissolution techniques for the characterization of amorphous solid dispersions are included. Progress in understanding of amorphous supersaturation or recrystallisation from solution gathered from mechanistic studies is discussed. Aspects of powder flow and compression are considered in a section on downstream processing. Overall, spray drying has a bright future due to its versatility, efficiency and the driving force of poorly soluble drugs.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs

Davis

Walker

2018

Journal of Controlled Release

125

View full text Add to dashboard Cite

show abstract

“…25 It was reported that the degree of succinoyl substitution has a notable impact on crystallization inhibition and pH-dependent solubility. 26 In a separate study, a dichloromethane: acetone mixture (75:25 v/v) was used to prepare ENZ/HPMC-AS spray-dried dispersions (SDD) by rotary evaporation. 27 The results confirm that having drug-rich aggregates could enhance the oral absorption of drugs.…”

Section: Introductionmentioning

confidence: 99%

Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions

Zhang

Rao

Qiu

et al. 2021

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

We demonstrated a facile approach, by adjusting the solvent ratio of water/acetone binary mixture, to alter the intermolecular interactions between Enzalutamide (ENZ) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) for spray drying process, which can be readily implemented to produce spray-dried dispersions (SDD) with enhanced stability and bioavailability.The prepared SDD of ENZ/HPMC-AS were examined systematically in terms of particle size, morphology, dissolution, solubility, stability, and bioavailability. Our results show that the introduction of water (up to 30% volume fraction) can effectively reduce the hydrodynamic diameter of HPMC-AS from approximately 220 nm to 160 nm (a reduction of c.a. 20%), which increases the miscibility of the drug and polymer, delaying or inhibiting the crystallization of ENZ during the spray drying process, resulting in a homogeneous amorphous phase. The benefits of using acetone/water binary mixture were subsequently evidenced by an increased specific surface area, improved dissolution profile and relative bioavailability, enhanced stability, and elevated drug release rate. This fundamental finding underpins the great potential of using binary mixture for spray drying process to process active pharmaceutical ingredients (APIs) that are otherwise challenging to handle.

show abstract

“…Chemical modification of a substance significantly affects the kinetics of its absorption and release from the body [331]. To change the properties of active substances, general pharmaceutical methods are used: the formation of salts, co-crystals, hydrates, solvates, and polymorphs [332,333].…”

Section: Prospects For the Creation Of Drugs For External Use Through...mentioning

confidence: 99%

Scientific Foundations in medicine and Pharmacy

Vladlenov¹

2022

View full text Add to dashboard Cite

All rights reserved. Printed in the United States of America. No part of this publication may be reproduced, distributed, or transmitted, in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher. The content and reliability of the articles are the responsibility of the authors. When using and borrowing materials reference to the publication is required. Collection of scientific articles published is the scientific and practical publication, which contains scientific articles of students, graduate students, Candidates and Doctors of Sciences, research workers and practitioners from Europe and Ukraine. The articles contain the study, reflecting the processes and changes in the structure of modern science.

show abstract

Modelling drug degradation in a spray dried polymer dispersion using a modified Arrhenius equation

Cited by 13 publications

References 40 publications

Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs

Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs

Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions

Scientific Foundations in medicine and Pharmacy

Contact Info

Product

Resources

About