Modelling cognitive outcomes in the UK Biobank: education, noradrenaline and frontoparietal networks
Laura Bravo-Merodio,
Jackie A Williams,
Dominic R Russ
et al.
Abstract:Cognitive reserve measured by proxies of life experiences is thought to account for the heterogeneity in cognitive ageing. One hypothesis is that cognitively enriched environments acting on the noradrenergic system strengthen the right fronto-parietal networks to facilitate cognitive reserve and maintain cognition throughout the lifetime. We used machine learning and mediation analysis to model interactions between neurobiological features (genetic variants in noradrenergic signalling, structural and functiona… Show more
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