Modelling chronic toxicokinetics and toxicodynamics of copper in mussels considering ionoregulatory homeostasis and oxidative stress

Alterations on the Activities of Ion ATPases in the Gill and Muscle of Freshwater Mussel (Unio tigridis) Exposed to Copper

“…The effects of Ag and Cr were remarkable as the activities of Na,K-ATPase, Ca-ATPase, and Mg-ATPase in the mussels (Perna viridis) as inhibitions of enzymes were evident (Vijayavel et al, 2007). It is commonly agreed that chronic toxicity of Cu at sublethal levels was associated with ionoregulatory disturbance (Le et al, 2021). The authors indicated that Cu might inhibit Na,K-ATPase activity by reducing the number of functional pump sites and the limited Cu-bound Na,K-ATPase turnover rate.…”

“…Similarly, metal concentrations in tissues of control Unio tigridis were found to be very low , suggesting there was no considerable metal contamination in the natural environment of mussels used in the present study. Laboratory experiments have shown that exposures to metals, including copper, affect the osmoregulation system of mussels, with significant fluctuations in ion ATPase activities (Viarengo et al, 1996;Vijayavel et al, 2007;Chandurvelan et al, 2013;Jorge et al, 2013;Le et al, 2021). These studies emphasized that while metals affected the osmoregulation system in mussels, several other factors such as metal concentration, duration, chemical properties of water, and biology of the species were found to be important.…”

Development of a toxicokinetic-toxicodynamic model simulating chronic copper toxicity to the Zebra mussel based on subcellular fractionation

“…Moreover, such a pattern of subcellular partitioning explains the high sensitivity of this organism to Cu as noticed in other studies (March et al, 2007). At a nominal exposure concentration of 25 µg/L, Cu was accumulated in the MAP at a lower rate (0.05-0.07 L/g/d) than the whole body uptake rate (0.09-0.11 L/g/d; Le et al, 2021b) (Table S4). This is indicative of an ability of this bivalve to detoxify accumulated Cu at this exposure level.…”

“…Model calibration was implemented using the MATLAB-based AMIGO2 toolbox as applied previously (Le et al, 2021b). The model was calibrated with data on: 1) the dissolved Cu concentration in water (Table S1, Supporting Information); 2) the Cu concentration in subcellular fractions (Fig.…”

Delineation of the exposure-response causality chain of chronic copper toxicity to the zebra mussel, Dreissena polymorpha, with a TK-TD model based on concepts of biotic ligand model and subcellular metal partitioning model

“…Toxicokinetic-toxicodynamic (TK-TD) models simulate the timecourse processes that determine adverse effects on organisms (Ashauer and Escher, 2010;Jager et al, 2011). With evident advantages, these models have been widely applied for predicting acute toxicity (Gao et al, 2015(Gao et al, , 2017Feng et al, 2018), and only recently for chronic toxicity (Le et al, 2021a). In most of the previous TK-TD models, the total internal concentration was considered the connecting point between the TK phase and the TD phase.…”