Modelling Cardiac Tissue Growth and Remodelling

Wang, Vicky Y.; Hussan, Jagir R.; Yousefi, Hashem; Bradley, Chris; Hunter, Peter; Nash, Martyn P.

doi:10.1007/s10659-017-9640-7

Cited by 19 publications

(11 citation statements)

References 94 publications

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“…Cellular growth is often considered to be the cause for residual stress . The myocardial stress and constitutive properties are considered to be the two key factors in myocardial G&R . There are typically two types of G&R modelling approaches at the continuum level.…”

Section: Introductionmentioning

confidence: 99%

Coupled agent‐based and hyperelastic modelling of the left ventricle post‐myocardial infarction

Zhuan

Luo

Gao

et al. 2018

Numer Methods Biomed Eng

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Understanding the healing and remodelling processes induced by myocardial infarction (MI) of the heart is important, and the mechanical properties of the myocardium post‐MI can be indicative for effective treatments aimed at avoiding eventual heart failure. MI remodelling is a multiscale feedback process between the mechanical loading and cellular adaptation. In this paper, we use an agent‐based model to describe collagen remodelling by fibroblasts regulated by chemical and mechanical cues after acute MI, and upscale into a finite element 3D left ventricular model. We model the dispersed collagen fibre structure using the angular integration method and have incorporated a collagen fibre tension‐compression switch in the left ventricle (LV) model. This enables us to study the scar healing (collagen deposition, degradation, and reorientation) of a rat heart post‐MI. Our results, in terms of collagen accumulation and alignment, compare well with published experimental data. In addition, we show that different shapes of the MI region can affect the collagen remodelling, and in particular, the mechanical cue plays an important role in the healing process.

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Section: Introductionmentioning

confidence: 99%

Coupled agent‐based and hyperelastic modelling of the left ventricle post‐myocardial infarction

Zhuan

Luo

Gao

et al. 2018

Numer Methods Biomed Eng

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“…In a review study on the modeling of cardiac growth, illustrative models of looping heart were presented in which bending configuration is controlled by the heterogeneous growth in a tube (Wang et al, 2017). In this study, a cellular model of cardiomyocyte growth in CellML (Cuellar et al, 2003) was coupled to a growth based finite element model of tissue deformation which was modeled using an open source platform, OpenCMISS (Bradley et al, 2011).…”

Section: Computational Models Of C-loopingmentioning

confidence: 99%

An integrative multiscale view of early cardiac looping

Ebrahimi

Bradley

Hunter

2021

WIREs Mechanisms of Disease

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The heart is the first organ to form and function during the development of an embryo. Heart development consists of a series of events believed to be highly conserved in vertebrates. Development of heart begins with the formation of the cardiac fields followed by a linear heart tube formation. The straight heart tube then undergoes a ventral bending prior to further bending and helical torsion to form a looped heart. The looping phase is then followed by ballooning, septation, and valve formation giving rise to a four-chambered heart in avians and mammals. The looping phase plays a central role in heart development.Successful looping is essential for proper alignment of the future cardiac chambers and tracts. As aberrant looping results in various congenital heart diseases, the mechanisms of cardiac looping have been studied for several decades by various disciplines. Many groups have studied anatomy, biology, genetics, and mechanical processes during heart looping, and have proposed multiple mechanisms. Computational modeling approaches have been utilized to examine the proposed mechanisms of the looping process. Still, the exact underlying mechanism(s) controlling the looping phase remain poorly understood.Although further experimental measurements are obviously still required, the need for more integrative computational modeling approaches is also apparent in order to make sense of the vast amount of experimental data and the complexity of multiscale developmental systems. Indeed, there needs to be an iterative interaction between experimentation and modeling in order to properly find the gap in the existing data and to validate proposed hypotheses.

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“…These detailed structural approaches are especially necessary to describe growth and remodeling (G&R) (138). Roughly speaking, there are two types of mechanisms underlying G&R responses to environmental cues.…”

Section: Future Directionsmentioning

confidence: 99%

A Contemporary Look at Biomechanical Models of Myocardium

Avazmohammadi

Soares

et al. 2019

Annu. Rev. Biomed. Eng.

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Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural observations, and specific test conditions to which they are fitted. We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium. We further explore the experimental and numerical techniques used to identify the model parameters. Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior. We conclude by pointing to future directions in the areas of optimal form as well as new approaches for constitutive modeling of myocardium.

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Modelling Cardiac Tissue Growth and Remodelling

Cited by 19 publications

References 94 publications

Coupled agent‐based and hyperelastic modelling of the left ventricle post‐myocardial infarction

Coupled agent‐based and hyperelastic modelling of the left ventricle post‐myocardial infarction

An integrative multiscale view of early cardiac looping

A Contemporary Look at Biomechanical Models of Myocardium

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