Modelling and optimization of polyphenol and antioxidant extraction from Rumex hastatus by green glycerol-water solvent according to response surface methodology

Anis, Nida; Ahmed, Dildar

doi:10.1016/j.heliyon.2022.e11992

Cited by 12 publications

(4 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Gibbs free energy change was calculated using Equation (7). ΔG = ΔH − T ⋅ ΔS (7) K = YT/Yu= mL/mS (8) where K is equilibrium constant, YT is the yield of polyphenols at temperature T, Yu is the percentage of the un-extracted polyphenols, mL is amount of polyphenols in liquid at equilibrium temperature T, ms is amount of polyphenols in solid at equilibrium temperature T, R is gas constant (8.314 J (molK) −1 ), while ΔH (Jmol −1 ), ΔS (Jmol −1 K -1 ), and ΔG (Jmol −1 ) are enthalpy, entropy, and Gibbs free energy changes, respectively.…”

Section: Thermodynamic Parametersmentioning

confidence: 99%

“…Multiple techniques and conditions are available to extract polyphenols from plant-based materials [6] Sridhar et al, 2021]. Employing mathematical modeling facilitates effective planning, improvement, and regulation of the investigative process [7] Anis and Ahmed 2022]. Various types of models, such as theoretical, empirical, and semi-empirical models, can simulate the extraction of bioactive substances from plant materials using solid-liquid extraction techniques.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling of polyphenols extraction process from green tea and the effect of temperature on the process

Levan Gulua,

Tamar Khutsidze,

Tamar Turmanidze

2024

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

Two mathematical models of polyphenols extraction from green tea leaves were tested: Peleg’s model and First-order model. Thermodynamical parameters of the process were determined. For the Peleg’s model we got the following analytical equation: Ct= t/(0.2570207+0.0324377*t). Ct is a concentration of polyphenols in extract at the time t. For the First-order model analytical equation describing the extraction process was as follows: Ct=23.09278*(1-exp(-0.1418264*t)). Goodness of fit of the both models were high but the first-order model prognosed equilibrium concentration of polyphenols in tea infusion with much more precisely than the Peleg’s model. Activation energy for the First-order model was equal to 2798 j/mol. Entropy change (ΔS) of this process was equal to 52 (J, (mol, K−1)), and enthalpy change (ΔH) was equal to 16304 (Jmol−1). The ΔG value gradually decreased as the extraction temperature increased, indicating that increasing the extraction temperature can make the extraction easier. First Order Model of tea polyphenols extraction was shown to be well describing the process. The most useful conditions for polyphenols extraction from green tea leaves were 70 ℃ and 20 min.

show abstract

Section: Thermodynamic Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling of polyphenols extraction process from green tea and the effect of temperature on the process

Levan Gulua,

Tamar Khutsidze,

Tamar Turmanidze

2024

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

show abstract

“…However, according to our experimental results, petroleum ether extraction may lead to the loss of certain flavonoids. Glycerol, a non-toxic green solvent, has been reported to have a high extraction efficiency in the extraction of plant phenolics [66][67][68]. Furthermore, glycerol-based deep eutectic solvents (DES) have been extensively researched for the extraction of plant phenolics [69,70].…”

Section: The Determination Of Total Flavonoid Content (Tfc)mentioning

confidence: 99%

Optimizing the Solvent Selection of the Ultrasound-Assisted Extraction of Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Phenolic Profiles and Antioxidant Activity

Wu,

Yang,

et al. 2024

Foods

View full text Add to dashboard Cite

Sea buckthorn pomace (SBP) is a by-product of sea buckthorn processing that is rich in bioactive compounds. In this study, different active ingredients were extracted by using different solvents (water, methanol, ethanol, glycerol, ethyl acetate, and petroleum ether) combined with an ultrasonic assisted method. The correlation between the active ingredients and antioxidant properties of the extract was studied, which provided a research basis for the comprehensive utilization of SBP. This study revealed that the 75% ethanol extract had the highest total phenolic content (TPC) of 42.86 ± 0.73 mg GAE/g, while the 75% glycerol extract had the highest total flavonoid content (TFC) of 25.52 ± 1.35 mg RTE/g. The ethanol extract exhibited the strongest antioxidant activity at the same concentration compared with other solvents. The antioxidant activity of the ethanol, methanol, and glycerol extracts increased in a concentration-dependent manner. Thirteen phenolic compounds were detected in the SBP extracts using UPLC-MS/MS analysis. Notably, the 75% glycerol extract contained the highest concentration of all identified phenolic compounds, with rutin (192.21 ± 8.19 μg/g), epigallocatechin (105.49 ± 0.69 μg/g), and protocatechuic acid (27.9 ± 2.38 μg/g) being the most abundant. Flavonols were found to be the main phenolic substances in SBP. A strong correlation was observed between TPC and the antioxidant activities of SBP extracts. In conclusion, the choice of solvent significantly influences the active compounds and antioxidant activities of SBP extracts. SBP extracts are a valuable source of natural phenolics and antioxidants.

show abstract

“…Consequently, the model provides a prediction of optimal experimental conditions. Moreover, the statistical designs substantially reduce the resources, time, and effort needed to develop the formulations [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology for Optimization of Hydrogel-Forming Microneedles as Rapid and Efficient Transdermal Microsampling Tools

Leanpolchareanchai

Nuchtavorn

2023

Gels

View full text Add to dashboard Cite

Microneedles (MNs) have shown a great potential for the microsampling of dermal interstitial fluid (ISF) in a minimally invasive manner for point-of-care testing (POCT). The swelling properties of hydrogel-forming microneedles (MNs) allow for passive extraction of ISF. Surface response approaches, including Box-Behnken design (BBD), central composite design (CCD), and optimal discrete design, were employed for the optimization of hydrogel film by studying the effects of independent variables (i.e., the amount of hyaluronic acid, GantrezTM S-97, and pectin) on the swelling property. The optimal discrete model was selected to predict the appropriate variables, due to the good fit of the experimental data and the model validity. The analysis of variance (ANOVA) of the model demonstrated p-value < 0.0001, R2 = 0.9923, adjusted R2 = 0.9894, and predicted R2 = 0.9831. Finally, the predicted film formulation containing 2.75% w/w hyaluronic acid, 1.321% w/w GantrezTM S-97, and 1.246% w/w pectin was used for further fabrication of MNs (525.4 ± 3.8 µm height and 157.4 ± 2.0 µm base width), which possessed 1508.2 ± 66.2% swelling, with 124.6 ± 7.4 µL of collection volume, and could withstand thumb pressure. Moreover, almost 50% of MNs achieved a skin insertion depth of approx. 400 µm, with 71.8 ± 3.2% to 78.3 ± 2.6% recoveries. The developed MNs show a promising prospect in microsample collection, which would be beneficial for POCT.

show abstract

Modelling and optimization of polyphenol and antioxidant extraction from Rumex hastatus by green glycerol-water solvent according to response surface methodology

Cited by 12 publications

References 62 publications

Modeling of polyphenols extraction process from green tea and the effect of temperature on the process

Modeling of polyphenols extraction process from green tea and the effect of temperature on the process

Optimizing the Solvent Selection of the Ultrasound-Assisted Extraction of Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Phenolic Profiles and Antioxidant Activity

Response Surface Methodology for Optimization of Hydrogel-Forming Microneedles as Rapid and Efficient Transdermal Microsampling Tools

Contact Info

Product

Resources

About