“…However, no effort has been made to develop a holistic framework that is applicable for in vivo gene therapy, and provides a model-based decision-making platform taking into account the main multi-objective optimization issues, which consequently forms the main objective of this paper. A literature survey revealed that while a number of research works have been done on model-based control of drug delivery (Dua, Dua, & Pistikopoulos, 2010), very little thought had been given to the development of control strategies for gene delivery systems (Dua, 2012;Jamili & Dua, 2016;Ma & Zhang, 2009). This paper presents the mathematical modeling, simulation and control of the dynamic process of non-viral siRNA delivery.…”