Modelling and numerical simulation of remodelling processes in cortical bone: An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Witt, Carina; Kaiser, Tobias; Menzel, Andreas

doi:10.1016/j.jmps.2022.105194

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…148 Piezoelectricity in collagen fibers, fluid-generated streaming potentials in bone microtubules and the flexoelectric effect in cortical bones are important electromechanical foundations for harnessing bone remodeling. 149,150 Hydroxyapatite significantly induced osteogenic differentiation after electropolarization treatment, while electropolarized synthetic carbonate-substituted apatite scaffolds also improved osteoclastic resorption through increased interfacial wettability. 151 Combining the tricalcium phosphate gelatin scaffold with electroacupuncture stimulation (ES) induced a pH change in the culture medium.…”

Section: Electrobiomaterialsmentioning

confidence: 99%

Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis

Chen,

Wang,

Yang

et al. 2024

Mater. Adv.

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Section: Electrobiomaterialsmentioning

confidence: 99%

Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis

Chen,

Wang,

Yang

et al. 2024

Mater. Adv.

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“…22 Also, a focused application of IGA was presented recently for flexoelectric-motivated healing of cracked bones. 23 However, IGA suffers from complexities in imposing higher-order Dirichlet boundary conditions. 24 Recent works have evolved to tackle known IGA gaps and overlap issues, 25 but still, application to flexoelectricity is inchoate.…”

Section: Introductionmentioning

confidence: 99%

“…The IGA is also enhanced for topology optimization in the context of strain gradient materials 21 and flexoelectric structures 22 . Also, a focused application of IGA was presented recently for flexoelectric‐motivated healing of cracked bones 23 . However, IGA suffers from complexities in imposing higher‐order Dirichlet boundary conditions 24 .…”

Section: Introductionmentioning

confidence: 99%

A novel 3D mixed finite element for flexoelectricity in piezoelectric materials

Serrao,

Kozinov

2024

Numerical Meth Engineering

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Flexoelectricity is the intrinsic length‐scale dependent higher‐order electromechanical response of all centro‐ and non‐centro‐symmetric dielectrics, including piezoelectrics. Direct flexoelectricity is defined as the appearance of an electric field due to induced strain gradients. The numerical modeling of flexoelectricity is largely carried out using mixed FE, which has its historical foundations in strain gradient theories. However, existing finite elements are either limited to 2D or have inherited numerical instabilities due to the known saddle‐point structuring. The current work presents a numerically robust three‐dimensional mixed FE for higher‐order electromechanical applications without the use of stabilization or penalty parameters. After its verification, the new finite element is applied to the new problem of truncated semicone torsion, taking into account flexoelectricity in piezoelectric solids, and the original findings are reported. Current research reveals the complex interaction between first‐order (piezoelectricity) and higher‐order (flexoelectricity) electromechanical coupling.

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Modelling and numerical simulation of remodelling processes in cortical bone: An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Cited by 5 publications

References 56 publications

Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis

Harnessing osteoimmunity to treat peri-implant inflammatory osteolysis

A novel 3D mixed finite element for flexoelectricity in piezoelectric materials

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

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