Modélisationin vitrode la barrière hémato-encéphalique

Abstract

The blood-brain barrier (BBB) is located at the brain microvessel level and isolates the brain from the whole body, thus restricting molecule and cell exchanges between cerebral and peripheral compartments. In order to better decipher and understand the BBB physiology and development, and to investigate transport mechanism and toxicity of neuropharmaceuticals, several in vitro BBB models have been developed using animal or human cells, primary or immortalized cells. The aim of this review is to explain to the reader the major criteria required for a pertinent in vitro BBB model and to briefly expose the different models currently available with their characteristics with a special focus on the static models.

Anti-Inflammatory Action of Resveratrol in the Central Nervous System in Relation to Glucose Concentration—An In Vitro Study on a Blood–Brain Barrier Model

“…Furthermore, in the realm of predicting BBB permeability, models can be categorized into monoculture, non-contact co-culture, and contact co-culture systems. Another classifying factor for BBB models is the species of origin of the cells applied, which includes animal models (e.g., mouse, rat, bovine, or porcine) and human models [ 78 , 79 ].…”

Anti-inflammatory action of resveratrol in the central nervous system in relation to glucose concentration - an in vitro study on a blood-brain barrier model

“…Furthermore, in the realm of predicting BBB permeability, models can be categorized into monoculture, non-contact co-culture, and contact co-culture systems. Another classifying factor for BBB models is the species of origin of the cells applied, which includes animal models (e.g., mouse, rat, bovine, or porcine) and human models [69,70].…”

Des peptides dérivés de claudines inhibent les infections à Flavivirus

“…Le peptide n'a également aucun effet sur l'attachement du ZIKV à la membrane de la cellule cible ou sur l'internalisation du virus par cette dernière, ce qui suggérait une action du peptide à une étape tardive de l'entrée des virions. Nous avons supposé que le peptide agit en inhibant la fusion du virus à sa cellule franchir la barrière hémato-encéphalique et à pénétrer dans le système nerveux central [2] (➜). Nous avions précédemment montré que la claudine-7, une protéine des jonctions intercellulaires serrées, favorise l'infection par le ZIKV des cellules endothéliales des vaisseaux cérébraux et périphériques in vitro [3].…”