Modeling ultrafiltration of complex biological solutions

Darnon, E.; Belleville, Marie‐Pierre; Rios, G.M.

doi:10.1002/aic.690480814

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…For this, experimental results in good agreement with predicted data by simulations are necessary. All required parameters for this model were derived from literature studies on biotechnological separation processes [25,28,43]. At first, simulations with this literature data were made to evaluate the accuracy and to determine a first set of model parameters.…”

Section: Experimental Studiessupporting

confidence: 40%

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Integration of Ultrafiltration Unit Operations in Biotechnology Process Design

2011

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A stepwise process design approach is proposed to model membrane unit operations generally in combination with experimental model parameter determination in laboratory scale, in order to predict the purification performance a priori by simulations for multicomponent mixtures. The development of a rigorous model for an ultrafiltration membrane is described. In conceptual process design, the degree of comprehension of all unit operations integrated have to be almost identical to be able of any consistent process proposal taking equipment-related fluid-dynamical and kinetic nonidealities besides thermodynamical feasibility into account. Therefore, a process model, combining the most limiting factors within one mathematical model, is established and various filtrations are carried out with a binary solution for validation. Additionally, a standard laboratory equipment is instituted for logging time-dependent concentration profiles. The practicability of the proposed procedure is proven in order to design and integrate ultrafiltration membranes into total purification processes.

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Section: Experimental Studiessupporting

confidence: 40%

“…Increasing the turbulence in fluid flow may reduce its effect. This can be obtained by increasing the flow velocity across the membrane surface or by using turbulence promoters [28].…”

Section: Limiting Factors In Membrane Processesmentioning

confidence: 47%

Integration of Ultrafiltration Unit Operations in Biotechnology Process Design

2011

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“…Experimental results in good agreement with predicted data from simulations are necessary to prove the experimental validity of the proposed modeling approach. All required parameters for the model were derived from literature studies on biotechnological separation processes [26][27][28]. To run simulations with unknown mixtures, it is important to develop key components representing a great amount of available components.…”

Section: Resultsmentioning

confidence: 40%

Integration of Reverse‐Osmosis Unit Operations in Biotechnology Process Design

2011

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The stepwise process design approach, proposed in a previous study, to generally model membrane unit operations in combination with experimental model parameter determination is transferred to a reverse-osmosis unit. In order to predict the purification a priori by simulations, the changes of the rigorous ultrafiltration model to gain a rigorous reverse-osmosis model are described. The modular process model, combining the most limiting factors within one mathematical model, is transmitted to reverse osmosis and various filtrations are carried out. Together with the new standard laboratory equipment, practicability of the proposed buildup is proven in order to design and integrate reverse-osmosis membranes into biotechnology processes.

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“…A small amount of original fermentation broth was available; it was abandoned from using a membrane with a MWCO of 50 kDa. For this reason the species involved in this study are two representative reference molecules: vitamin B12 and immunoglobulin G (IgG) 68, 69. Vitamin B12 was chosen because of its good UV activity and the huge field of application in experimental studies.…”

Section: Resultsmentioning

confidence: 99%

Downstream of downstream processing: development of recycling strategies for biopharmaceutical processes

Grote¹,

Ditz²,

Strube³

2012

J of Chemical Tech & Biotech

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BACKGROUND: Downstream processing plays a crucial role in biotechnological production processes. Product concentration and purification require complex, multi-step operations, using significant amounts of chemical and auxiliary material. Today, design and optimization is important because the process development of biotechnological products is becoming more and more expensive. It is of great importance to improve sustainable development of eco-efficient products and processes. Integrated process and product development leads to more efficient use of raw materials.

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Modeling ultrafiltration of complex biological solutions

Cited by 13 publications

References 17 publications

Integration of Ultrafiltration Unit Operations in Biotechnology Process Design

Integration of Ultrafiltration Unit Operations in Biotechnology Process Design

Integration of Reverse‐Osmosis Unit Operations in Biotechnology Process Design

Downstream of downstream processing: development of recycling strategies for biopharmaceutical processes

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