“…Only recently, Karadimitriou et al (2014) proposed a method to estimate such state variables from experimental measurements, while Schluter et al (2016) and McClure et al (2018) provided alternative approaches to identify the missing variables in terms of integral geometry (i.e., Euler characteristics). Over the years, more practical and ad hoc formulations of the relative permeabilities have been proposed (Chierici, 1984;Clavier et al, 2017;Dehghanpour et al, 2011;Gunstensen & Rothman, 1993;Li et al, 2018;Oliveira & Demond, 2003;Pasquier et al, 2017;Yiotis et al, 2007;Zhang et al, 2018), including the study of the impact of spatial heterogeneity on relative permeabilities (Jackson et al, 2018). To the best of our knowledge, a general formulation that accounts for the phase topology at the pore-scale of a 3-D porous medium has not been proposed yet.…”