Modeling trauma to develop treatments for posttraumatic stress.

Lowery-Gionta, Emily G.; May, Matthew; Taylor, Rachel M; Bergman, Elizabeth M.; Etuma, Mahder T.; Jeong, Isaac; Simmons, Laurence; Ventura, Matthew; Capaldi, Vincent F.; Matson, Liana M.; Moore, Nicole L.

doi:10.1037/tps0000199

Cited by 5 publications

(3 citation statements)

References 276 publications

(362 reference statements)

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“…In general, individuals in military, police, or other first responder jobs can be exposed to major, frequent, or prolonged stressful events throughout the course of their employment. We know from animal-based research that all of these types of events can elicit stress and or/PTSD-like responses, which likely explains the prevalence of this disorder category within the OSI population [13]. PTSD involves one or more traumatic events (traumas) that are experienced, witnessed, or learned about by the person exposed to them [11].…”

Section: Trauma-and Stressor-related Disordersmentioning

confidence: 99%

Operational Stress Injury

Rudnick,

Shaheen,

Lefurgey

et al. 2023

Encyclopedia

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An operational stress injury (OSI) is a term used most often to describe mental disorders which result from, or are exacerbated by, military or police service. In the Canadian context, this most often refers to active or former members of the Canadian Armed Forces (CAF) or the Royal Canadian Mounted Police (RCMP). The most common diagnoses within this term include post-traumatic stress disorder (PTSD), anxiety disorders, depression, and substance use disorders.

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Section: Trauma-and Stressor-related Disordersmentioning

confidence: 99%

Operational Stress Injury

Rudnick,

Shaheen,

Lefurgey

et al. 2023

Encyclopedia

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“…Animal models have been integral to the understanding of the effects of a variety of stress exposures on neurophysiological and neurobehavioral processes [22]. Many models rely on one form of stress presented in a single exposure or over repeated exposures to provoke measurable responses, typically behavioral, endocrine, or physiological in nature.…”

Section: Development Of Medications For Operational Use In the Far Te...mentioning

confidence: 99%

Management of Acute Stress Reactions in the Military: A Stepped Care Approach

Matson

Adler

Quartana

et al. 2022

Curr Psychiatry Rep

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Purpose of the Review This review highlights knowledge gaps surrounding the development and use of interventions for Acute Stress Reactions (ASRs). First, we propose that a stepped care approach to intervention for ASR be developed and utilized in military operational environments. A stepped care approach would include detection and assessment, followed by behavioral intervention, and then medication intervention for ASRs. Second, we discuss potential strategies that can be taken for the development of safe and effective ASR medications. Recent Findings ASRs commonly occur in operational environments, particularly in military populations. ASRs impact the safety and performance of individual service members and teams, but there are currently limited options for intervention. Summary Efforts to improve ASR detection and assessment, and development and delivery of ASR interventions for implementation in operational environments, will be critical to maintaining the safety and performance of service members.

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“…As reviewed in the current special issue, animal models have provided a breadth of knowledge related to neurodevelopmental and psychiatric disorders involving substance use and dependence, deregulated impulse control and motivated behaviors, stress related pathophysiology, and intervention targets (Bale et al, 2019). In the current issue, Lowery-Gionta et al (2019) highlight that links between proinflammatory markers and posttraumatic stress disorder (PTSD) in humans are currently under study in animal models suggesting previously unrealized connections between the neuroimmune axis and PTSD-like behavioral outcomes. In addition, preclinical studies in animal models have identified potential therapeutic targets for PTSD treatment across multiple neurochemical systems.…”

mentioning

confidence: 99%

Translating animal models into empirical foundations for practice.

Threlkeld¹,

Maddox²,

James³

et al. 2019

Translational Issues in Psychological Science

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Animal models have been used widely to study a broad range of behaviors and disorders. Current animal models provide a window into behavioral mechanisms across the lifespans, allowing researchers to investigate complex epigenetic interactions, cellular processes and the organization and dysregulation of neuronal systems. The present editorial for the special issue of Translational Issues in Psychological Science, "Animal Models as Empirical Foundations for Practice", highlights a few contemporary uses of animal models in psychological science. Here we focus on three articles using animal models to investigate gambling behavior, alcohol abuse and posttraumatic stress related neurobehavioral processes. We close this editorial with the observation that advances in biomedical science will further facilitate the use of animal models as empirical foundations for practice in the psychological sciences.Editor's Note. This is an editorial to the special issue "Animal Models as Empirical Foundations for Practice." Please see the Table of Contents here:

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Modeling trauma to develop treatments for posttraumatic stress.

Cited by 5 publications

References 276 publications

Operational Stress Injury

Operational Stress Injury

Management of Acute Stress Reactions in the Military: A Stepped Care Approach

Translating animal models into empirical foundations for practice.

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