“…Thrombotic models that employ molecular, cellular/tissue, fluid, microfluidic and physiological descriptions have rarely been used in practical QSP for pharmacokinetic and pharmacodynamic computation. 61 Models of signal transduction 14,15,62 and blood coagulation in vitro 63,64 are used to provide limited mechanism-driven molecular-level insights. As a result, simpler models with fewer parameters, rather than complex QSP physiological models, are more often utilized to explore fundamental hypotheses about thrombus generation and drug discovery/development.…”