Modeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in humanin vivo
Pierre Giroux,
Jérôme Vialaret,
Jana Kindermans
et al.
Abstract:The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net result of protein synthesis and degradation, but also transport across biological compartments. We report an accurate 3-biological compartment model able simultaneously account for the protein dynamics observed in … Show more
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