Modeling the nuclear magnetic resonance behavior of lung: From electrical engineering to critical care medicine

Cutillo, A; Ailion, David C.

doi:10.1002/(sici)1521-186x(1999)20:4+<110::aid-bem13>3.0.co;2-f

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…An UTE sequence was used to have a limited sensitivity to the apparent relaxation rate R 2 * variations after administration. Because the signal decay within the lung is complex , assuming an exponential decay only reflects the trends for frequency dispersion induced by magnetic field inhomogeneity, and R 2 * is a phenomenological parameter reflecting it. The assumptions of either neglecting variations or assuming exponential decay are approximations.…”

Section: Discussionmentioning

confidence: 99%

Aerosol deposition in the lungs of spontaneously breathing rats using Gd‐DOTA‐based contrast agents and ultra‐short echo time MRI at 1.5 Tesla

Wang

Sebrié

Ruaud

et al. 2015

Magnetic Resonance in Med

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Section: Discussionmentioning

confidence: 99%

Aerosol deposition in the lungs of spontaneously breathing rats using Gd‐DOTA‐based contrast agents and ultra‐short echo time MRI at 1.5 Tesla

Wang

Sebrié

Ruaud

et al. 2015

Magnetic Resonance in Med

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“…The T1W allows visualizing lung parenchyma and anatomy. Reduced R2* suggests enhanced hemorrhage or edema in the TV16-EV30 group [32]. 19 F signal shows PFC residues.…”

Section: Morphological Effects Of Total Liquid Ventilation On Lung Stmentioning

confidence: 94%

A new paradigm for lung-conservative total liquid ventilation

et al. 2020

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Background: Total liquid ventilation (TLV) of the lungs could provide radically new benefits in critically ill patients requiring lung lavage or ultra-fast cooling after cardiac arrest. It consists in an initial filling of the lungs with perfluorocarbons and subsequent tidal ventilation using a dedicated liquid ventilator. Here, we propose a new paradigm for a lung-conservative TLV using pulmonary volumes of perfluorocarbons below functional residual capacity (FRC). Methods and findings: Using a dedicated technology, we showed that perfluorocarbon end-expiratory volumes could be maintained below expected FRC and lead to better respiratory recovery, preserved lung structure and accelerated evaporation of liquid residues as compared to complete lung filling in piglets. Such TLV below FRC prevented volutrauma through preservation of alveolar recruitment reserve. When used with temperature-controlled perfluorocarbons, this lung-conservative approach provided neuroprotective ultra-fast cooling in a model of hypoxic-ischemic encephalopathy. The scale-up and automating of the technology confirmed that incomplete initial lung filling during TLV was beneficial in human adult-sized pigs, despite larger size and maturity of the lungs. Our results were confirmed in aged non-human primates, confirming the safety of this lung-conservative approach. Interpretation: This study demonstrated that TLV with an accurate control of perfluorocarbon volume below FRC could provide the full potential of TLV in an innovative and safe manner. This constitutes a new paradigm through the tidal liquid ventilation of incompletely filled lungs, which strongly differs from the previously known TLV approach, opening promising perspectives for a safer clinical translation. Fund: ANR (COOLIVENT), FRM (DBS20140930781), SATT IdfInnov (project 273).

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Magnetic Resonance Imaging of the Thorax

Sperber¹

2001

Radiologic Diagnosis of Chest Disease

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Modeling the nuclear magnetic resonance behavior of lung: From electrical engineering to critical care medicine

Cited by 3 publications

References 21 publications

Aerosol deposition in the lungs of spontaneously breathing rats using Gd‐DOTA‐based contrast agents and ultra‐short echo time MRI at 1.5 Tesla

Aerosol deposition in the lungs of spontaneously breathing rats using Gd‐DOTA‐based contrast agents and ultra‐short echo time MRI at 1.5 Tesla

A new paradigm for lung-conservative total liquid ventilation

Magnetic Resonance Imaging of the Thorax

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