Modeling the Impact of Sensitivity Distribution Variations of Tetrapolar Impedance Configurations in Microfluidic Analytical Devices

Hantschke, Martin; Triantis, Iasonas F.

doi:10.1109/jsen.2020.3019170

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…This estimated performance compares very favourably with the regulatory limit and other LOD and LOQ values from Table I. Such an advancement has great potential to enhance modern bio-microsystem sensors [69], [70]. Our work also has the potential to advance beyond lock-in fluorescence systems that were not largely applied for biological applications [71].…”

Section: (B)supporting

confidence: 56%

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

et al. 2023

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This work introduces a sensor for dairy antibiotic detection of ciprofloxacin in milk. We provide an important tool for antibiotic detection in milk and the main contributions of this work are as follows. We introduce a technique based on florescence spectroscopy and lock-in amplification for sensing ciprofloxacin in milk that is capable of detection below the regulatory limit. We compare the system against one without the integrated lock-in amplification, as in traditional fluorescence sensors. We provide microchip capillary electrophoresis results and place our work in context for future integration with microchip capillary electrophoresis.

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Section: (B)supporting

confidence: 56%

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

et al. 2023

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“…Depending on the application, improvements to the bipolar topology can be made by employing a four-electrode/tetrapolar configuration, where one pair of electrodes is used to inject the current while the other one carries out the sensing voltage. In the latter, one pair of electrodes injects the current, while another pair measures the voltage, greatly minimising the effects of the electrode–electrolyte interface and enhancing measurement accuracy [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The primary source of errors in bipolar bioimpedance systems, including typical corneometers, relates to the electrode–electrolyte double layer introducing a contact impedance that can significantly interfere with the measured value [ 10 ]. As measurements are taken across a range of frequencies (typically up to 1 MHz), the detrimental effect of the contact impedance varies significantly, especially when small electrodes and/or low frequencies are employed [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Multi-Modal Spectroscopic Assessment of Skin Hydration

Gidado,

Nwokoye,

Triantis

et al. 2024

Sensors

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Human skin acts as a protective barrier, preserving bodily functions and regulating water loss. Disruption to the skin barrier can lead to skin conditions and diseases, emphasizing the need for skin hydration monitoring. The gold-standard sensing method for assessing skin hydration is the Corneometer, monitoring the skin’s electrical properties. It relies on measuring capacitance and has the advantage of precisely detecting a wide range of hydration levels within the skin’s superficial layer. However, measurement errors due to its front end requiring contact with the skin, combined with the bipolar configuration of the electrodes used and discrepancies due to variations in various interfering analytes, often result in significant inaccuracy and a need to perform measurements under controlled conditions. To overcome these issues, we explore the merits of a different approach to sensing electrical properties, namely, a tetrapolar bioimpedance sensing approach, with the merits of a novel optical sensing modality. Tetrapolar bioimpedance allows for the elimination of bipolar measurement errors, and optical spectroscopy allows for the identification of skin water absorption peaks at wavelengths of 970 nm and 1450 nm. Employing both electrical and optical sensing modalities through a multimodal approach enhances skin hydration measurement sensitivity and validity. This layered approach may be particularly beneficial for minimising errors, providing a more robust and comprehensive tool for skin hydration assessment. An ex vivo desorption experiment was carried out on fresh porcine skin, and an in vivo indicative case study was conducted utilising the developed optical and bioimpedance sensing devices. Expected outcomes were expressed from both techniques, with an increase in the output of the optical sensor voltage and a decrease in bioimpedance as skin hydration decreased. MLR models were employed, and the results presented strong correlations (R-squared = 0.996 and p-value = 6.45 × 10−21), with an enhanced outcome for hydration parameters when both modalities were combined as opposed to independently, highlighting the advantage of the multimodal sensing approach for skin hydration assessment.

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Advances in the design and application of contactless conductivity detectors for separation, flow-through, microfluidic and sensing techniques: A review

Tůma

2024

Analytica Chimica Acta

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Modeling the Impact of Sensitivity Distribution Variations of Tetrapolar Impedance Configurations in Microfluidic Analytical Devices

Cited by 4 publications

References 39 publications

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

Lock-in Amplifier Dairy Sensor for Detection of Ciprofloxacin

Multi-Modal Spectroscopic Assessment of Skin Hydration

Advances in the design and application of contactless conductivity detectors for separation, flow-through, microfluidic and sensing techniques: A review

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