Abstract:Chromatographic workstations can
significantly impact column chromatography
performance by altering the peak shape and retention time. Inclusion
of system contributions can help prevent misinterpretation of process
data during column qualification, process scale-up, tech transfer
to a different facility, or the implementation of equipment changes
over the product life cycle. Holdup volumes, not usually considered,
can pose significant risks during process development. Using bench-scale
and pilot-scale AKTA chr… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.