This study describes a new assessment model framework, termed the driving forces-pressure-state-impact-policy and pattern (DPSIP) model, for environmental change efficiency in urban land development, based on urban sustainable development and the theory of economic efficiency evaluation. A spatial and measurable efficiency value is defined for environmental changes in urban land development, which provides a comprehensive evaluation index for the efficiency of urban development and its environmental impact. This type of urban interior sustainability is considered new within the context of global environmental changes. We identify nine important indicators to evaluate the relative efficiency of 233 neighborhoods in Tainan, Taiwan. The results indicate that the average environmental change efficiency is 89.44%, which shows clear spatial differentiation. The key indicators affecting the efficiency score are area, population density, location, mixed land uses, the floor area ratio, and the impervious ratio. In the future, urban design can reduce environmental impacts and enhance efficiency values.