Modeling the Effects of Human Neutrophil Elastase on Coagulation Failure and Fibrinolysis

Barrett, Christopher D.; Bird, Molly A.; Moore, Hunter B.; Moore, Ernest E.; Yaffe, Michael B.

doi:10.1016/j.jamcollsurg.2018.08.643

Cited by 1 publication

(1 citation statement)

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“…An overly procoagulant state brought on by excessive inflammation is what causes thromboembolism. Antiphospholipid antibodies, abnormal coagulation, and lupus anticoagulant are all present in patients with severe COVID-19 [67]. Thromboembolism is treated with prophylactic or anticoagulation therapy for COVID-19, using heparin.…”

Section: Elastase and Thrombinmentioning

confidence: 99%

Elastase and COVID-19 relationship, and potential natural resource as elastase inhibitors: A comprehensive review

Ambarwati¹,

Desmiaty²,

Ahmad³

et al. 2023

J App Biol Biotech

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SARS-Cov-2 is the culprit behind the acute respiratory syndrome COVID-19. Immunopathological mechanisms that cause excessive inflammation and neutrophil activation cause this syndrome. Neutrophils are crucial for the removal of viruses and other infectious agents. This study aims to comprehensively examine the relationship between elastase enzymes and COVID-19, as well as natural resources as elastase inhibitors. The literature was searched using electronic databases such as Directory Open-Access Journal, Google Scholar, National Health Institute, PubMed, ScienceDirect, and Web of Science between October 2021 and August 2022. This narrative review article highlights some aspects of the relationship between elastase and COVID-19, including the general pathophysiology of COVID-19, protease enzymes and protease inhibitors, neutrophil extracellular traps (NET), NET cell death, elastin and desmosine, elastase and antielastase, elastase and thrombin, elastase and angiotensin-converting enzyme 2 (ACE2), elastase and cathepsin C, correlation of elastase and COVID-19, COVID-19 therapy, and natural products resource as elastase inhibitors.

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Section: Elastase and Thrombinmentioning

confidence: 99%