Modeling the Drug Release from Hydrogel-Based Matrices

Caccavo, Diego; Cascone, Sara; Lamberti, Gaetano; Barba, Anna Angela

doi:10.1021/mp500563n

Cited by 95 publications

(73 citation statements)

References 35 publications

(73 reference statements)

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“…Mass transport parameters determine how nutrients, gasses, waste products, and bioactive agents, such as growth factors and drugs are exchanged within gels or are delivered by them. Except in hydrogels with very large micropores or forced flow conditions, convection usually does not play a significant role in the movement of solutes through hydrogel matrices and diffusion alone is commonly regarded as the driving transport phenomenon 19,20 .…”

Section: Introductionmentioning

confidence: 99%

On the parallelism between the mechanisms behind chromatography and drug delivery: the role of interactions with a stationary phase

Rossi

Castiglione

Salvalaglio

et al. 2017

Phys. Chem. Chem. Phys.

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A huge number of studies and works in drug delivery literature are focused on understanding and modeling transport phenomena, the pivotal point for a good device design. The rationalization of all phenomena involved is fundamental, but several concerns arise leaving many issues unsolved. In order to change point of view we decided to focus our attention on parallelisms between two fields that seem to be very far each other: chromatography and drug release. Taking advantages on the studies conducted by many researchers with chromatographic columns we decided to explain all the phenomena involved in drug delivery considering sodium ibuprofen molecules (IP) as analytes and hydrogel as stationary phase. In particular we considered not only diffusion, but also drug-polymer interactions as adsorption on the stationary phase and drug-drug interactions as analytes aggregation. Hydrogel investigated is a promising formulation made of agarose and carbomer 974p (AC) loaded with IP, a non-steroidal common anti-inflammatory drugs. The self-diffusion coefficient of IP in AC formulations was measured by using an innovative method based on Magic Angle Spinning NMR spectroscopic technique to produce High Resolution (liquid-like) spectra.This method (HR-MAS NMR) is used in combination with pulsed field gradient spin echo (PGSE) liquid-state techniques. The model predictions satisfactorily match with experimental data obtained in water and the gel environment, indicating that the model presented here, despite its simplicity, is able to describe the key phenomena governing the device behavior and could be used to rationalize the experimental activity.!

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Section: Introductionmentioning

confidence: 99%

On the parallelism between the mechanisms behind chromatography and drug delivery: the role of interactions with a stationary phase

Rossi

Castiglione

Salvalaglio

et al. 2017

Phys. Chem. Chem. Phys.

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“…The controlled drug release from hydrogels is an important issue for medical applications that has been under intensive investigation in the last decades, both experimentally (Hoare and Kohane, 2008;Ratner and Hoffman, 1976) or through mathematical modelling (Peppas and Khare, 1993;Siepmann and Siepmann, 2008), including empirical/semi-empirical models, as well as mechanistic realistic ones (Caccavo et al, 2015a(Caccavo et al, , 2015bKaunisto et al, 2010;Lamberti et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion

Pimenta

Ascenso

Fernandes

et al. 2016

International Journal of Pharmaceutics

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Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorhexidine, levofloxacin and diclofenac. Equilibrium partition coefficients were determined at different ionic strength and pH, using water (pH 5.6) and PBS (pH 7.4). The measured partition coefficients were related with the polymer volume fraction in the hydrogel, through the introduction of an enhancement factor following the approach developed by the group of C. J. Radke (Kotsmar et al., 2012;Liu et al., 2013). This factor may be decomposed in the product of three other factors , and which account for, respectively, hard-sphere size exclusion, electrostatic interactions, and specific solute adsorption. While and are close to 1, >>1 in all cases suggesting strong specific interactions between the drugs and the hydrogels. Adsorption was maximal for chlorhexidine on the silicone based hydrogel, in water, due to strong hydrogen bonding.The effective diffusion coefficients, , were determined from the drug release profiles.Estimations of diffusion coefficients of the non-adsorbed solutes = × allowed comparison with theories for solute diffusion in the absence of specific interaction with the polymeric membrane.

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“…Diffusion alone is commonly regarded as the driving transport phenomenon. [14][15][16] Despite the high simplicity,i nt erms of mass transport for chemical engineering applications, several problems arise;a vailables tudies often show low or even no accordance to descriptive theories and, more generally,t his topic is still much debated. [17,18] Several works on drug-delivery systems are centered on pure Fickian diffusion with degradationa nd swelling contributions.…”

Section: Introductionmentioning

confidence: 99%

The Role of Drug–Drug Interactions in Hydrogel Delivery Systems: Experimental and Model Study

et al. 2016

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To address the increasing need for improved tissue substitutes, tissue engineering seeks to create synthetic, three-dimensional scaffolds made from polymeric materials able to incorporate cells and drugs. The interpretation of transport phenomena is a key step, but comprehensive theoretical data is still missing and many issues related to these systems are still unsolved. In particular, the contribution of solute-solute interactions is not yet completely understood. Here, we investigate a promising agar-carbomer (AC) hydrogel loaded with sodium fluorescein (SF), a commonly used drug mimetic. The self-diffusion coefficient of SF in AC formulations was measured by using high resolution magic angle spinning NMR spectroscopy (HR-MAS NMR). Starting from experimental data, a complete overview on SF transport properties is provided, in particular a mathematical model that describes and rationalizes the differences between gel and water environments is developed and presented. The hydrogel molecular environment is able to prevent SF aggregation, owing to the adsorption mechanism that reduces the number of monomers available for oligomer formation at low solute concentration. Then, when all adsorption sites are saturated free SF molecules are able to aggregate and form oligomers. The model predictions satisfactorily match with experimental data obtained in water and the gel environment, thus indicating that the model presented here, despite its simplicity, is able to describe the key phenomena governing device behavior and could be used to rationalize experimental activity.

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Modeling the Drug Release from Hydrogel-Based Matrices

Cited by 95 publications

References 35 publications

On the parallelism between the mechanisms behind chromatography and drug delivery: the role of interactions with a stationary phase

On the parallelism between the mechanisms behind chromatography and drug delivery: the role of interactions with a stationary phase

Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion

The Role of Drug–Drug Interactions in Hydrogel Delivery Systems: Experimental and Model Study

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