Modeling the biomechanical and injury response of human liver parenchyma under tensile loading

Untaroiu, Costin D.; Lu, Yuan-Chiao; Siripurapu, Sundeep Krishna; Kemper, Andrew R.

doi:10.1016/j.jmbbm.2014.07.006

Cited by 22 publications

(26 citation statements)

References 37 publications

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“…The quantitative study of injury to tissues has been the focus of several reports but is difficult to study [32,[34][35][36]. Damage to tissue or organs is often documented in qualitative ways using terms such as fractures and lacerations [37], without a clear delineation of what is acceptable or unacceptable damage [38,39].…”

mentioning

confidence: 99%

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear

Chen

Brazile

Prabhu

et al. 2018

Journal of Biomechanical Engineering

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In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and shear loading conditions using an interrupted mechanical testing method. To capture the internal microstructural changes in response to global deformation, the tissue samples were loaded to different strain levels and chemically fixed to permanently preserve the deformed tissue geometry. Tissue microstructural alterations were analyzed to quantify the accumulated damages, with damage-related parameters such as number density, area fraction, mean area, and mean nearest neighbor distance (NND). All three loading states showed a unique pattern of damage evolution, in which the damages were found to increase in number and size, but decrease in NND as strain level increased. To validate the observed damage features as true tissue microstructural damages, more samples were loaded to the above-mentioned strain levels and then unloaded back to their reference state, followed by fixation. The most major damage-relevant features at higher strain levels remained after the release of the external loading, indicating the occurrence of permanent inelastic deformation. This study provides a foundation for future structure-based constitutive material modeling that can capture and predict the stress-state dependent damage evolution in liver tissue.

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mentioning

confidence: 99%

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear

Chen

Brazile

Prabhu

et al. 2018

Journal of Biomechanical Engineering

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“…This could be a critical topic for future research to connect size and shape FE models of internal organs and bones. In addition, the size and shape models of the human liver could be further combined with distributions of liver material properties Untaroiu et al, 2014) to develop probabilistic FE models of the liver (Laz and Browne, 2010). Using these probabilistic FE human models in impact simulations could help to better understand the variability observed in biomechanical and injury response of the abdominal organs under impact loading (Untaroiu, 2010;Untaroiu et al, 2012), to improve future anthropometric test devices (ATDs) used in compliant and regulatory testing (Parent et al, 2013;Putnam et al, 2014;Ridella and Parent, 2011), and probably to design advanced restraint systems which may take into account the occupant anthropometry (Adam and Untaroiu, 2011;Untaroiu and Adam, 2013).…”

Section: Discussionmentioning

confidence: 99%

A statistical geometrical description of the human liver for probabilistic occupant models

Lu¹,

Untaroiu²

2014

Journal of Biomechanics

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“…It was successfully used for modelling abdominal tissues, like porcine, bovine, and human liver [13,30,62,64,111,113,114], porcine kidney [101,112], and porcine spleen [112]. Most of the mechanical test data available for brain tissue are fitted today with an Ogden hyperelastic model [15,52,53,57,[90][91][92].…”

Section: Ogden Modelmentioning

confidence: 99%

“…Untaroiu and Lu [113] Bovine liver parenchyma 1 Untaroiu et al [114] Human liver parenchyma 1 Yin et al [121] Human cirrhotic liver � Zaeimdar [122] Veal liver and kidney behaviour of the liver and kidney tissues [26,30,48,55,62,64,99,101,[111][112][113][114]122]. Comparison of the ability of the Mooney-Rivlin model with two material parameters and the Ogden model of the third order to fit the compression behaviour of porcine liver tissue was performed by Hu and Desai [48].…”

Section: Spleenmentioning

confidence: 99%

Isotropic incompressible hyperelastic models for modelling the mechanical behaviour of biological tissues: a review

Wex

Arndt

Stoll

et al. 2015

Biomedical Engineering / Biomedizinische Technik

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Modelling the mechanical behaviour of biological tissues is of vital importance for clinical applications. It is necessary for surgery simulation, tissue engineering, finite element modelling of soft tissues, etc. The theory of linear elasticity is frequently used to characterise biological tissues; however, the theory of nonlinear elasticity using hyperelastic models, describes accurately the nonlinear tissue response under large strains. The aim of this study is to provide a review of constitutive equations based on the continuum mechanics approach for modelling the rate-independent mechanical behaviour of homogeneous, isotropic and incompressible biological materials. The hyperelastic approach postulates an existence of the strain energy function--a scalar function per unit reference volume, which relates the displacement of the tissue to their corresponding stress values. The most popular form of the strain energy functions as Neo-Hookean, Mooney-Rivlin, Ogden, Yeoh, Fung-Demiray, Veronda-Westmann, Arruda-Boyce, Gent and their modifications are described and discussed considering their ability to analytically characterise the mechanical behaviour of biological tissues. The review provides a complete and detailed analysis of the strain energy functions used for modelling the rate-independent mechanical behaviour of soft biological tissues such as liver, kidney, spleen, brain, breast, etc.

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Modeling the biomechanical and injury response of human liver parenchyma under tensile loading

Cited by 22 publications

References 37 publications

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear

A statistical geometrical description of the human liver for probabilistic occupant models

Isotropic incompressible hyperelastic models for modelling the mechanical behaviour of biological tissues: a review

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