Modeling strategies for enantiomers separation by SMB chromatography

Pais, L.S.; Loureiro, José M.; Rodrigues, Alı́rio E.

doi:10.1002/aic.690440307

Cited by 172 publications

(112 citation statements)

References 25 publications

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“…Also, the influence of the degree of subdivision of the bed in the SMB model predictions was analyzed and compared with the TMB performance. A complete study, with comparison between experimental and model results, can be found elsewhere [9]. The main conclusion of this study is that the deviations between TMB and SMB predictions (averaged over a switch time interval) decrease as the degree of subdivision of the bed increases.…”

Section: Smb Strategies Of Modelingmentioning

confidence: 85%

“…The TMB operating conditions and model parameters are summarized in Table 3. A recycling flow-rate of 27.95 ml/min in the TMB corresponds to a recycling flow-rate of 35.38 ml/min in the SMB; a TMB solid flow-rate of 11.15 ml/min corresponds to a switch time interval of 3 min in the SMB unit [9]. The total inlet or outlet flow-rates were kept constant in all simulations and equal to 25.09 ml/min.…”

Section: Simulation Resultsmentioning

confidence: 99%

“…A good agreement between model and experimental results are obtained for k= 0.1 s − 1 . As it was shown in a previous work [9], it is valid to compare the experimental SMB results with the ones obtained by modeling using the TMB model, when two or more columns per section are used in the SMB system. Fig.…”

Section: Experimental Operation Of a Smb Pilot Unitmentioning

confidence: 99%

See 2 more Smart Citations

Chiral separation by SMB chromatography

Pais

Loureiro

Rodrigues

2000

Separation and Purification Technology

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The paper deals with chiral separation by simulated moving bed (SMB) chromatography. A model for the prediction of the cyclic steady-state performance of the SMB, based on the analogy with the true moving bed (TMB), is developed assuming multicomponent adsorption equilibria, axial dispersion flow and the linear driving force approximation to describe the intraparticle mass transfer rate. The simulation package is used to predict the effect of operating variables on the process performance and to define the regions for enantiomers separation. The influence of mass transfer resistance in the separation region is analyzed. A practical tool for choosing the better SMB operating conditions as a function of the feed flow-rate is proposed. The experimental operation of a pilot unit of SMB, Licosep 12-26 (Novasep, France), is carried out for the separation of enantiomers and illustrated with two systems: the bi-naphthol and the chiral epoxide enantiomers. Experimental results and model predictions are compared in terms of process performance and internal concentration profiles.

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Section: Smb Strategies Of Modelingmentioning

confidence: 85%

Section: Simulation Resultsmentioning

confidence: 99%

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Chiral separation by SMB chromatography

Pais

Loureiro

Rodrigues

2000

Separation and Purification Technology

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“…As it was shown in a previous work, [17] for SMB units with, at least, two columns per section, the steady-state performance as well as the concentration internal profiles can be properly evaluated by using the TMB model. For the particular chiral system studied in this work and described later, and for the operating conditions and model parameters presented later in Table 4, numerical simulations using both SMB and TMB models show very similar results in terms of extract and raffinate purities.…”

Section: Design Of Smb Chiral Separationsmentioning

confidence: 93%

Design of SMB Chiral Separations Using the Concept of Separation Volume

Rodrigues

Pais

2005

Separation Science and Technology

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The article deals with chiral separation by simulated moving bed (SMB) chromatography. When mass transfer resistances are negligible, equilibrium theory provides explicit criteria for the choice of the SMB operating conditions. However, in the presence of mass transfer resistances, the SMB operating conditions should be evaluated through simulation. Using a package based on the analogy with the true moving bed operation, this work shows how mass transfer resistance can affect the conditions for enantiomers separation, as well as the critical values stated by equilibrium theory. The concept of separation volume is applied to show how the flow-rate constraints, in presence of mass transfer

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“…Fortunately, a small subdivision of the bed is sufficient to ensure that an SMB unit performs close to the ideal TMB countercurrent operation. We concluded that the prediction of the SMB operation can be carried out through the equivalent TMB approach when the SMB unit is constituted by, at least, two columns per section (a total of eight columns) [11]. However, we should not forget that recent applications in the pharmaceutical industry use SMB systems containing a low total number of columns, for instance, a total of five or six columns.…”

Section: Preparative Enantioselective Chromatographymentioning

confidence: 99%