Modeling responses of Daphnia magna to pesticide pulse exposure under varying food conditions: intrinsic versus apparent sensitivity

Pieters, Barry J.; Jager, Tjalling; Kraak, Michiel H.S.; Admiraal, Wim

doi:10.1007/s10646-006-0100-6

Cited by 57 publications

(38 citation statements)

References 36 publications

(44 reference statements)

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“…Therefore, these results are the first to present chronic oral toxicity data for 2,4-D and propiconizole and the most recent for arsenic. There are numerous additional advantages in using DEBtox models for the analysis of this type of toxicity data, even where only survival is recorded32333435363738. In the DEBtox model structure, there is an intimate relationship between survival and toxicokinetics; uptake of the chemical to a level above the NEC is required for effects on survival above background mortality to occur.…”

Section: Discussionmentioning

confidence: 99%

Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling

Hesketh

Lahive

Horton

et al. 2016

Sci Rep

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Concern over reported honeybee (Apis mellifera spp.) losses has highlighted chemical exposure as a risk. Current laboratory oral toxicity tests in A. mellifera spp. use short-term, maximum 96 hour, exposures which may not necessarily account for chronic and cumulative toxicity. Here, we use extended 240 hour (10 day) exposures to examine seven agrochemicals and trace environmental pollutant toxicities for adult honeybees. Data were used to parameterise a dynamic energy budget model (DEBtox) to further examine potential survival effects up to 30 day and 90 day summer and winter worker lifespans. Honeybees were most sensitive to insecticides (clothianidin > dimethoate ≫ tau-fluvalinate), then trace metals/metalloids (cadmium, arsenic), followed by the fungicide propiconazole and herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). LC50s calculated from DEBtox parameters indicated a 27 fold change comparing exposure from 48 to 720 hours (summer worker lifespan) for cadmium, as the most time-dependent chemical as driven by slow toxicokinetics. Clothianidin and dimethoate exhibited more rapid toxicokinetics with 48 to 720 hour LC50s changes of <4 fold. As effects from long-term exposure may exceed those measured in short-term tests, future regulatory tests should extend to 96 hours as standard, with extension to 240 hour exposures further improving realism.

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Section: Discussionmentioning

confidence: 99%

Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling

Hesketh

Lahive

Horton

et al. 2016

Sci Rep

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“…Review on fenitrothion There were four papers in which experimental data were collected for the purposes of predictory modelling of effects (Ashauer et al (2007b), Ashauer et al (2007a), Beyers et al (1999), Pieters et al (2006). While evaluating the data it came into focus that many research papers used "outdoor" set-ups (21 in total) ranging from artificial streams to monitoring and sampling of real application sites.…”

Section: Supporting Publications 2012:en-347 11mentioning

confidence: 99%

Repeated and multiple stress (exposure to pesticides) on aquatic organisms

Dennis

Tiede

Thompson

2012

EFSA Supporting Publications

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A systematic literature search identified publications relevant to repeated (94 papers) and mixture exposure (152 papers) of aquatic organisms. Limited data are available on pulsed exposure of pesticides and reports on repeated pulse or fluctuating exposures are even rarer. Although there has been recognition of the need for more realistic testing scenarios these lack a systematic approach. Among the reports on pesticide mixtures most of the plant studies evaluated interactions between mixtures of herbicides or fungicides / algicides. A small number of reports evaluated the effects on invertebrates of mixtures of pesticides with the same mode of action and these showed additive toxicity. More studies in invertebrates assessed interactions between pesticides with different modes of action including herbicide/ insecticide combinations some of which showed toxicity greater than additive. The majority of studies in fish have investigated the toxicity of insecticide mixtures. The toxicity of most combinations was at most additive, with a small number antagonistic. A small number of papers reported mixture effects of pesticides in amphibians; more than additive effects were observed with atrazine combinations. Simple models can be used to determine the additive toxicity of pesticide mixtures based on concentration addition or independent action. More complex models to determine the scale of synergy are species-and dose-dependent and rely on an understanding of the interactions involved. Further work is required to develop a greater understanding of the species, dose and time dependence of exposure to pesticide mixtures in which more complex interactions occur. In the interim, in the majority of cases the increase in toxicity is no greater than 3 fold when compared to additive, the deviation from additivity decreases with the increasing number of components in the mixture, and where no known interactions have been reported this may be an appropriate factor to include in risk assessments. KEY WORDSPulsed, mixtures, pesticides, aquatic organisms, synergism, additive effects DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors 1 Question No EFSA-Q-2011-00786. Repeated and Multiple Stress in Aquatic OrganismsSupporting publications 2012:EN-347 2The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the...

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“…Trophic state may determine the response of individuals, populations, and ecosystems to chemicals through modifying resource availability (Noel et al, 2006;Pieters et al, 2006;Alexander et al, 2013;De Hoop et al, 2013;Gabsi et al, 2014). The degree of isolation will determine if immigration from areas with lower exposure levels can compensate for chemical effects and/or facilitate recovery and recolonization (Liess and Schulz, 1999;Caquet et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Theoretically exploring direct and indirect chemical effects across ecological and exposure scenarios using mechanistic fate and effects modelling

Laender

Morselli

Baveco

et al. 2015

Environment International

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Modeling responses of Daphnia magna to pesticide pulse exposure under varying food conditions: intrinsic versus apparent sensitivity

Cited by 57 publications

References 36 publications

Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling

Extending standard testing period in honeybees to predict lifespan impacts of pesticides and heavy metals using dynamic energy budget modelling

Repeated and multiple stress (exposure to pesticides) on aquatic organisms

Theoretically exploring direct and indirect chemical effects across ecological and exposure scenarios using mechanistic fate and effects modelling

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