Modeling platinum resistance in a stem-like patient-derived ovarian cancer sample
Tise Suzuki,
Ashlyn Conant,
Yeonkyu Jung
et al.
Abstract:Background Chemoresistance and tumor recurrence remain a significant challenge in ovarian cancer. Particularly in the context of platinum resistance, many mechanisms have been identified, including the activation of cellular processes like epithelial-mesenchymal transition (EMT), which generates cells with stemness characteristics. Current models of platinum resistance are limited or not adequate representations of the heterogeneity of the disease. Thus, to advance our understanding of chemoresistance in the c… Show more
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