Modeling paternal attentiveness: Distressed pups evoke differential neurobiological and behavioral responses in paternal and nonpaternal mice

Lambert, Kelly G.; Franssen, Catherine L.; Hampton, Joseph E.; Rzucidlo, Amanda; Hyer, Molly M.; True, M.; Kaufman, Casey; Bardi, Massimo

doi:10.1016/j.neuroscience.2012.12.023

Cited by 26 publications

(11 citation statements)

References 37 publications

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“…Corroborating evidence for this theoretical framework is also found in paternal behavior in which decreased activation of amygdala cells (via fos-immunoreactive cells) was correlated with increased motivation to approach offspring in the monogamous biparental California deer mouse, compared to the closely related uniparental common deer mouse (Lambert et al, 2011); additionally, fos-immunoreactivity, as well as oxytocinimmunoreactive fibers, were observed in the PVN in paternal mice (Lambert et al, 2011;Lambert et al, 2013). Focusing on juvenile male rats, the mPOA appears to play a role in pup-sensitized parental behavior (Rosenblatt et al, 1996).…”

Section: Accepted Manuscriptmentioning

confidence: 80%

Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress

Pawluski

Lambert

Kinsley

2016

Hormones and Behavior

109

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This article is part of a Special Issue "Parental Care". It is becoming clear that the female brain has an inherent plasticity that is expressed during reproduction. The changes that occur benefit the offspring, which in turn secures the survival of the mother's genetic legacy. Thus, the onset of maternal motivation involves basic mechanisms from genetic expression profiles, to hormone release, to hormone-neuron interactions, all of which fundamentally change the neural architecture - and for a period of time that extends, interestingly, beyond the reproductive life of the female. Although multiple brain areas involved in maternal responses are discussed, this review focuses primarily on plasticity in the maternal hippocampus during pregnancy, the postpartum period and well into aging as it pertains to changes in cognition. In addition, the effects of prolonged and repeated stress on these dynamic responses are considered. The maternal brain is a marvel of directed change, extending into behaviors both obvious (infant-directed) and less obvious (predation, cognition). In sum, the far-reaching effects of reproduction on the female nervous system provide an opportunity to investigate neuroplasticity and behavioral flexibility in a natural mammalian model.

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Section: Accepted Manuscriptmentioning

confidence: 80%

Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress

Pawluski

Lambert

Kinsley

2016

Hormones and Behavior

109

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“…In fact, Rosenblatt et al (1996) refer to sensitization in male rats as maternal behavior, because in this species only females display parental behavior under natural conditions. In this context, it is notable that both biparental California mice and uniparental white-footed mice ( Peromyscus maniculatus ) show increases in Fos-ir in the MPOA in response to pups (Lambert et al, 2013). More recent studies, therefore, have focused on neural and endocrine influences on paternal behavior in biparental species, in which both parents provide infant care under natural conditions (Bales et al, 2011b).…”

Section: Neuroanatomical Basis Of Paternal Behaviormentioning

confidence: 99%

Fathering in rodents: Neurobiological substrates and consequences for offspring

Bales

Saltzman

2016

Hormones and Behavior

125

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Paternal care, though rare among mammals, is routinely displayed by several species of rodents. Here we review the neuroanatomical and hormonal bases of paternal behavior, as well as the behavioral and neuroendocrine consequences of paternal behavior for offspring. Fathering behavior is subserved by many of the same neural substrates which are also involved in maternal behavior (for example, the medial preoptic area of the hypothalamus). While gonadal hormones such as testosterone, estrogen, and progesterone, as well as hypothalamic neuropeptides such as oxytocin and vasopressin, and the pituitary hormone prolactin, are implicated in the activation of paternal behavior, there are significant gaps in our knowledge of their actions, as well as pronounced differences between species. Removal of the father in biparental species has long-lasting effects on behavior, as well as on these same neuroendocrine systems, in offspring. Finally, individual differences in paternal behavior can have similarly long-lasting, if more subtle, effects on offspring behavior. Future studies should examine similar outcome measures in multiple species, including both biparental species and closely related uniparental species. Careful phylogenetic analyses of the neuroendocrine systems presumably important to male parenting, as well as their patterns of gene expression, will also be important in establishing the next generation of hypotheses regarding the regulation of male parenting behavior.

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“…Males of certain rodent species can express paternal behavior. With the exception of parturition and lactation, male California deer mice exhibit the same parental responses toward offspring as conspecific females (Lambert et al, 2013). Adult neurogenesis in the olfactory system has been examined in the process of fatherhood in this species.…”

Section: Regulation Of Olfactory Neurogenesis During Pregnancy and Thmentioning

confidence: 99%

Chemical olfactory signals and parenthood in mammals

Corona

Lévy

2015

Hormones and Behavior

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Modeling paternal attentiveness: Distressed pups evoke differential neurobiological and behavioral responses in paternal and nonpaternal mice

Cited by 26 publications

References 37 publications

Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress

Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress

Fathering in rodents: Neurobiological substrates and consequences for offspring

Chemical olfactory signals and parenthood in mammals

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