Modeling of Vibrational Spectra of L-tryptophan in Condensed States

Баранов, В. И.; Shcherbakova, N. E.; Слепченков, М. М.; Glukhova, Olga E.; Ten, G. N.

doi:10.18500/1817-3020-2017-17-1-20-32

2017

DOI: 10.18500/1817-3020-2017-17-1-20-32

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Modeling of Vibrational Spectra of L-tryptophan in Condensed States

В. И. Баранов¹,

N. E. Shcherbakova²,

М. М. Слепченков³

et al.

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2024

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Cited by 2 publications

References 17 publications

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Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs

Silva,

Pereira Silva,

Ramos Silva

et al. 2023

Crystal Growth & Design

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Different methods were explored for the amorphization of ranolazine, a sparingly soluble anti-anginal drug, such as mechanochemistry, quench-cooling, and solvent evaporation from solutions. Amorphous phases, with T g values lower than room temperature, were obtained by cryo-milling and quench-cooling. New forms of ranolazine, named II and III, were identified from the relaxation of the ranolazine amorphous phase produced by cryo-milling, which takes place within several hours after grinding. At room temperature, these metastable polymorphs relax to the lower energy polymorph I, whose crystal structure was solved in this work for the first time. A binary co-amorphous mixture of ranolazine and tryptophan was produced, with three important advantages: higher glass transition temperature, increased kinetic stability preventing relaxation of the amorphous to crystalline phases for at least two months, and improved aqueous solubility. Concomitantly, the thermal behavior of amorphous tryptophan obtained by cryo-milling was studied by DSC. Depending on experimental conditions, it was possible to observe relaxation directly to the lower energy form or by an intermediate metastable crystalline phase and the serendipitous production of the neutral form of this amino acid in the pure solid phase.

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Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs

Silva,

Pereira Silva,

Ramos Silva

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

Inclusion Complex of Gd(III) with β-Cyclodextrin and L-Tryptophan

Khasaeva,

Bukov,

Ivanin

et al. 2024

Žurnal obŝej himii

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Modeling of Vibrational Spectra of L-tryptophan in Condensed States

Cited by 2 publications

References 17 publications

Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs

Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs

Inclusion Complex of Gd(III) with β-Cyclodextrin and L-Tryptophan

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