Modeling of the fluid structure interaction of a human trachea under different ventilation conditions

Malvè, Mauro; Palomar, Amaya Pérez del; Trabelsi, Olfa; López-Villalobos, José Luis; Ginel, A.; Doblaré, M.

doi:10.1016/j.icheatmasstransfer.2010.09.010

Cited by 28 publications

(27 citation statements)

References 28 publications

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“…Comparing rabbit trachea with human trachea (which presents an anisotropic behavior), the stress range working on the muscular membrane is almost ten times smaller. 30,32 For both cartilage and muscle, since no preferential orientation was revealed, the Demiray strain energy density function W ¼ D 1 exp D 2 ðI 1 À 3Þ À Á À 1 Â Ã þ UðJÞ was used to fit the experimental results. In this function I 1 is the first invariant of the deviatoric right CauchyGreen tensor C ¼ J À2=3 F T F, J ¼ detðFÞ is the Jacobian, F is the standard deformation gradient, U is the volumetric energy function and D 1 , D 2 are material constants summarized in Table 2.…”

Section: Experimental Tensile Testmentioning

confidence: 99%

“…The fluid-solid coupling used by this software is extensively explained in literature 2 and it was explained in detail in previous studies. 30,32 The fluid and solid grids for each computed case were imported separately in the software. Then, the computational models, consisting of separated merging computational meshes, constitutive fluid and structural models and the boundary conditions, were created.…”

Section: Simulations Of the Stent Opening And Fsi Computationsmentioning

confidence: 99%

“…The length of these extrusions was taken as 5 times the diameter of the trachea as performed in previous studies. 29,32 This yields to a length of 27.5 mm for each inlet and for each outlet extension.…”

Section: Simulations Of the Stent Opening And Fsi Computationsmentioning

confidence: 99%

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On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison

et al. 2015

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Stenting technique is employed worldwide for treating atherosclerotic vessel and tracheal stenosis. Both diseases can be treated by means of metallic stents which present advantages but are affected by the main problem of restenosis of the stented area. In this study we have built a rabbit trachea numerical model and we have analyzed it before and after insertion and opening of two types of commercial stent: a Zilver R Flex T M Stent and a WallStent T M . In experimental parallel work, two types of stent were implanted in 30 New Zealand rabbits divided in two groups of 10 animals corresponding to each stent type and a third group made up of 10 animals without stent. The tracheal wall response was assessed by means of computerized tomography by endoscopy, macroscopic findings and histopathological study 90 days after stent deployment. Three idealized trachea models, one model for each group, were created in order to perform the computational study.The animal model was used to validate the numerical findings and to attempt to find qualitative correlations between numerical and experimental results. Experimental findings such as inflammation, granuloma and abnormal tissue growth, assessed from histomorphometric analyses were compared with derived numerical parameters such as wall shear stress (WSS) and maximum principal stress. The direct comparison of these parameters and the biological response supports the hypothesis that WSS and tensile stresses may lead to a greater tracheal epithelium response within the stented region, with the latter seeming to have the dominant role. This study may be helpful for improving stent design and demonstrates the feasibility offered by in-silico investigated tracheal structural and fluid dynamics.

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Section: Experimental Tensile Testmentioning

confidence: 99%

Section: Simulations Of the Stent Opening And Fsi Computationsmentioning

confidence: 99%

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On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison

et al. 2015

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“…The reconstruction of the trachea and the description of the properties of its constitutive modeling were extensively described in previous studies [26,18,19,21]. For this reason we provide here only a brief summary.…”

Section: Tracheal Solid Modelmentioning

confidence: 99%

“…However, these do not take the airway deformation into account and are focused on providing detailed information of the flow features in each pulmonar branch. More recently, fluid solid interaction studies performed for tracheal geometries tube and single or multiple bifurcations can be found in literature [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Computational fluid-dynamics optimization of a human tracheal endoprosthesis

Malvè

Barreras

López-Villalobos

et al. 2012

International Communications in Heat and Mass Transfer

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An Emulsion Approach to Resolve the Paradox of 3D Printing of Very Soft Silicones

Perrinet

Courtial

Colly

et al. 2020

Adv Materials Technologies

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3D printing of silicone has been a challenge for medical applications for several years. The main property of medical silicone (mostly polydimethylsiloxane) is its mechanical similitude with human tissues. The very soft tissues as prostate, skin, liver, etc, are of Young's modulus lower than 100 kPa. 3D printing for such soft materials is not as obvious as printing thermoplastic polymers. In this work, the goal is to elaborate formulations of room‐temperature‐vulcanizing (RTV) silicone leading to final materials of Young's modulus down to 25 kPa while being processable by liquid deposition modeling, a layer by layer deposit of extruded filament. The main challenge is keeping the material with a sufficient firmness during the process to maintain the shape of the object but without increasing its final rigidity. Therefore, a RTV silicone is mixed with a hydrophilic liquid to create an emulsion of high yield stress behavior. Different emulsions are tested to optimize the composition on the basis of rheological measurements carried out to determine the yield stress variation and compare it to an emulsion model. Then, after printing and curing, the hydrophilic liquid is removed to create a material of fine porosity and consequently of low Young's modulus.

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Modeling of the fluid structure interaction of a human trachea under different ventilation conditions

Cited by 28 publications

References 28 publications

On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison

On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison

Computational fluid-dynamics optimization of a human tracheal endoprosthesis

An Emulsion Approach to Resolve the Paradox of 3D Printing of Very Soft Silicones

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