The reasonable control of the grate cooler is the key factor to ensure the heat exchange and cement clinker quality during the clinker cooling process. In this paper, the cement grate cooler pressure of the grate cooler is taken as the research object and a cement grate cooler pressure prediction model is proposed based on the analysis of the current status of the automatic control of the grate cooler. This model uses a multi-model fusion neural network algorithm that combines a BP neural network, a support vector machine and classification and regression trees with a neural network structure. Furthermore, the multimodel fusion quality characteristics are proposed, and the root mean square error and Pearson linear correlation coefficient of the multi-model fusion quality characteristics are used as the evaluation indicators for the prediction results of the multi-model fusion neural network. After the analysis of the cooling process of the cement clinker, we select seven input variables, and then complete the data preprocessing and model parameter selection. Finally, we predict the cement grate cooler pressure using a multi-model fusion neural network, a BP neural network, a support vector machine and classification and regression trees with three training sets to test sets ratios. Through the comparison of the root mean square error and the Pearson linear correlation coefficient evaluation indicators and their change trends, as well as the display and analysis of the final modelling results, it is found that the multi-model fusion neural network algorithm can greatly improve the accuracy of the prediction of the grate pressure, and at the same time it has good practicality for the accurate prediction of the cement grate cooler pressure in the industry.