Modeling of modifier‐solute peak interactions in chromatography

Two-Phase Flow in Liquid Chromatography, Part 1: Experimental Investigation and Theoretical Description

“…This enrichment can be due to different reasons, such as the interaction of different adsorbing components, as was recently observed for the system phenetole (PNT) and 4-tert-butylphenole on the adsorbent Zorbax 300SB-C18. 1,2 Other reasons might be the impact of modifiers/sample solvents 3,4 or chemical reactions occurring in chromatographic reactors. Since standard chromatographic models do not account for the phenomena of phase split and two-phase flow, model descriptions fail at the conditions where these phenomena occur.…”

Development of the Wade equation for the description of elution peak profile by using second-order rate equations for the sorption kinetics

“…The ideal model is the simplest among them, which considers only the influence of the equilibrium thermodynamics of chromatography on the band profile (Guiochon, 2002;Strohlein et al, 2006). With the nomenclature used in the Wade's work (Wade et al, 1987), the ideal model can be written as:…”

Wave interactions and stability of the Riemann solutions for the chromatography equations

“…In order to analyze the behavior of chromatographic column in the extent of equilibrium theory, we should consider the initial boundary value problem consisting of the horizontal axis t = 0 with 0 x 1 and the vertical axis x = 0 and x = 1 for t 0 [9,13,20]. In fact, to solve this problem is similar to solve (1.1) and (1.3), namely, wave interactions should be dealt with completely.…”