Modeling of microbubbles pushed through clots via acoustic radiation force

Guarini, Ascanio; Everbach, E. Carr

doi:10.1121/1.4800645

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2 Mechanisms Of Thrombolytic Enhancement1

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2016

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“…Bader et al (2015) found a correlation between the root-mean-square velocity of displaced in-vitro human whole blood clots and the lytic rate with sub-megahertz insonation. Radiation force is known to act on bubbles (Leighton 1994), and several groups have shown microbubbles forced into clots in-vitro (Caskey et al 2009; Acconcia et al 2013; Everbach and Guarini 2013) (Fig. 19.1).…”

Section: 2 Mechanisms Of Thrombolytic Enhancementmentioning

confidence: 99%

Sonothrombolysis

Bader¹,

Bouchoux²,

Holland³

2016

Advances in Experimental Medicine and Biology

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Thrombo-occlusive disease is a leading cause of morbidity and mortality. In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported. Primary thrombus formation during cardiovascular disease and standard treatment methods will be discussed. Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed. Finally, in-vitro, in-vivo and clinical evidence of enhanced thrombolytic efficacy with ultrasound will be presented and discussed.

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