Modeling of metabolic diseases – a review of selected methods

Świerkosz, Agnieszka

doi:10.1515/bams-2015-0016

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…If the goal is to make a detailed model of one part of the glycolysis, it can be very different compared to a model of the overall cellular homeostatic function (Ackerman et al, 1965;Swierkosz, 2015). In the latter case, the underlying model structure which would include signalling events from other cellular species is perhaps more important than details about certain enzymatic steps.…”

Section: Introductionmentioning

confidence: 99%

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017

2017

Linköping Electronic Conference Proceedings

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Welcome to the 58th Conference on Simulation Modelling and Optimization in Reykjavik, Iceland. Reykjavik is the northernmost and one of the smallest capital cities in the world. Although small for a capital, it is the country's largest and most populated city and with the urban area population of around 200000, it is the home of the vast majority of Iceland's people. The city is pioneer in the use of geothermal energy to provide low-cost heating and electricity. Iceland's energy consumption per capita is among the highest in the world, and the proportion of this consumption provided by renewable energy sources exceeds most other countries. The electricity is produced almost entirely from renewable energy sources, hydroelectric (70%) and geothermal (30%) and simulation, modelling and optimization are the key elements to utilize the renewable energy more efficiently.The SIMS 58 will cover broad aspects of simulation, modelling and optimization and be a technical forum for participants to further their knowledge by being exposed to diverse topics, and exchange opinions and ideas both from industry and academia in a variety of topics related to simulation, modelling and optimization. The ambition is to bring the field of applied modelling and simulation techniques of energy systems to the general public as a contributing technology for efficient and sustainable energy systems. This year, the conference program contains two keynote speakers, 53 research papers and presentations organized into 14 sessions and an excursion to a geothermal park.The focus of the conference is on simulation, modelling and optimization in a variety of applied contexts including topics such as geothermal, hydro and bio energy, oil production, automotive industry and methodology and technologies for simulation, modelling and optimization.A key component of the SIMS conference is the opportunity to socialize and make new connections. The conference offers several possibilities such as a conference dinner at Bryggjan Brugghús (Bistro and Brewery), an excursion to the Reykjanes GEOPARK and last but not least some coffee and lunch breaks.SIMS stands for the Scandinavia Simulation Society with members from five Nordic countries, Denmark, Finland, Norway, Sweden and Iceland. The goal of SIMS is to develop further the science and practice of modelling and simulation in all application areas and to be a forum for information interchange between professionals and non-professionals in the Nordic countries.Thanks to all participants, authors, keynote speakers and presenters for their contribution to this conference. I also want to acknowledge the support I have received from the conference board, program committee and the SIMS board. The support from the National energy authority, Iceland is gratefully acknowledged.Welcome, I hope you will enjoy the conference and the interactions with your colleagues and other presenter here.Magnus Excursion:The conference excursion will be on Wednesday, September 27 th , at 10:00. Resource Park in the Reykjanes pen...

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Section: Introductionmentioning

confidence: 99%

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017

2017

Linköping Electronic Conference Proceedings

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The impact of signalling kinetics on controller motif performance

Risvoll

Drengstig

2017

Linköping Electronic Conference Proceedings

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In this paper we investigate how the disturbance rejection properties of physiological regulatory systems depend on the signalling kinetics between the biochemical species being considered as controlled and manipulated variables. Based on the mathematical model of a physiological regulatory system, we analyse the impact of three different signalling models, i.e. linear signalling, first order and second order Hill kinetics. We separate the analysis in two parts. First we identify to what extend the signalling from the manipulated variable to the controlled variable affect the range and ratio of manageable disturbances. In the second part we investigate whether and how the signalling from the controlled variable to the manipulated variable will affect the parameters of the controller part of the regulatory system. In this context, saturable Hill kinetics display advantages compared to linear signalling.

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Modeling of metabolic diseases – a review of selected methods

Cited by 2 publications

References 3 publications

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017

Proceedings of the 58th Conference on Simulation and Modelling (SIMS 58) Reykjavik, Iceland, September 25th – 27th, 2017

The impact of signalling kinetics on controller motif performance

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