Modeling of kyphoplasty cement for accurate dose calculations

Abstract

We have determined the optimal method for modeling kyphoplasty cement to enable accurate dose calculations in the Eclipse treatment planning system (TPS). The cement studied (Medtronic Kyphon HV-R ®) consists of 30% Barium, 68% polymethylmethacrylate (PMMA), and 2% benzoyl peroxide, formulated to be radiopaque with kV imaging systems. Neither Barium nor PMMA have a high physical density, resulting in different interaction characteristics for megavoltage treatment beams compared to kV imaging systems. This can lead to significant calculation errors if density mapping is performed using a standard CT number to density curve. To properly characterize the cement for dose calculation, we 3D printed a hemi-cylindrical container to fit adjacent to a micro-chamber insert for an anthropomorphic phantom, and filled the container with Kyphon cement. We CT scanned the combination, modeled the cement with multiple material assignments in the TPS, designed plans with different field sizes and beam geometry for five photon modes, and measured the doses for all plans. All photon energies show significant error in calculated dose when the cement is modeled based on the CT number. Of the material assignments we evaluated, polytetrafluoroethylene (PTFE) showed the best overall agreement with measurement. Calculated and measured doses agree within 3.5% for a 340-degree arc technique (which averages transmission and scatter effects) with the Acuros XB algorithm and PTFE as the assigned material. To confirm that PTFE is a reasonable substitute for kyphoplasty cement, we performed measurements in a slab phantom using rectangular inserts of cement and PTFE, showing average agreement of all photon modes within 2%. Based on these findings, we conclude that the PTFE material assignment provides acceptable dose calculation accuracy for the AAA and Acuros XB photon algorithms in the Eclipse TPS. We recommend that the cement be delineated as a structure and assigned the PTFE material for accurate dose calculation.

Application of a linear interpolation algorithm in radiation therapy dosimetry for 3D dose point acquisition

“…In AAA, the 3D pencil beam convolution/superposition algorithm uses a source model consisting of primary bremsstrahlung photons, extra focal photons, and contaminating electrons 3 . AAA uses model parameters with physical significance (such as photon energy spectrum, mean radial energy, and scatter kernels) to describe the characteristics of photon and electron fluence and their energy spectra in the treatment beam 36 . As a result, it is capable of reflecting the actual transport process of ionizing radiation during its calculation.…”