Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV

Sripan, Patumrat; Cœur, Sophie Le; Amzal, Billy; Ingsrisawang, Lily; Traisathit, Patrinee; Ngo‐Giang‐Huong, Nicole; McIntosh, Kenneth; Cressey, Tim R.; Sangsawang, Suraphan; Rawangban, Boonsong; Kanjanavikai, Prateep; Tréluyer, Jean‐Marc; Jourdain, Gonzague; Lallemant, Marc; Urien, Saı̈k

doi:10.1371/journal.pone.0126647

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…This HIV therapeutic approach was used in clinical trial as well as in routine care of HIV-infected pregnant women 33,41,42. In Burkina-Faso, ART has been shown to impact MTCT by reducing HIV maternal viral load,6,10 by providing effective pre-exposure prophylaxis to babies and by functioning as post-exposure prophylaxis for newborns 43–45…”

Section: Discussionmentioning

confidence: 99%

<p>Prevention of mother-to-child transmission (PMTCT) of HIV: a review of the achievements and challenges in Burkina-Faso</p>

Linguissi¹,

Sagna²,

Soubeïga³

et al. 2019

HIV

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Background Burkina-Faso’s HIV/AIDS program is one of the most successful in Africa, with a declining HIV prevalence and treatment outcomes that rival those of developed countries. Prevention of mother-to-child transmission (PMTCT) guidelines in Burkina-Faso, initiated in the year 2000, were revised in 2004, 2006 and 2010. The guideline document has since undergone several stages of improvement, largely based on recommendations from WHO, with adaptations by local experts in the field. Option B+ adopted since August 2014 in Burkina-Faso has enabled maintenance of mothers on longer treatment and increasing their survival and that of their children. Through this review, we describe the achievements and challenges of HIV PMTCT programs in Burkina-Faso. Aims of study This study had the following objectives: 1) describing the historical perspective of PMTCT implementation in Burkina-Faso; 2) presenting the effectiveness of interventions at improving PMTCT service delivery and promoting retention of mothers and babies in care; and 3) determining the impact of male partner involvement on PMTCT in Burkina-Faso. Methodology A literature search was conducted in PubMed and Google. Search terms included the following keywords: “HIV testing”; “prevention”; “mother”; “child”; “male partner”; “counseling”; “involvement”; “participation”; and the grouped terms “PMTCT and partners”; “VCT”; “barriers and/or factors”; “Male involvement in PMTCT”; and “Burkina-Faso”. Data collection took place from May to October 2015. The search was limited to articles published between January 2002 and December 2015. UNICEF and UNAIDS web sites were also used to find relevant abstracts and documents. Results Studies have revealed that with PMTCT, HIV transmission rate moved from 10.4% in 2006 to 0% in 2015. The PMTCT program remains the best way to care for HIV-infected pregnant women and their babies. The current PMTCT policy is based on evidence that male partner involvement is associated with women’s completion of PMTCT. Conclusion This study shows that the reduction in mother to child transmission of HIV in Burkina-Faso over the years is mainly due to the improvement of PMTCT programs. Efforts still need to be made about the involvement of male partners.

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Section: Discussionmentioning

confidence: 99%

<p>Prevention of mother-to-child transmission (PMTCT) of HIV: a review of the achievements and challenges in Burkina-Faso</p>

Linguissi¹,

Sagna²,

Soubeïga³

et al. 2019

HIV

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“…This mode of transmission is caused by contact with infectious agents during passage through the birth canal, and refers to the exposure of the newborn's mucosa to maternal blood and other infected secretions during the baby's passage through the birth canal. 17,26 It is worth mentioning that all pregnant women must receive, on the day of delivery, AZT IV, loading dose and maintenance doses, according to the dosage schedule of injectable zidovudine. It must be started three hours before the beginning of the cesarean section, the period necessary to reach the adequate intracellular concentration of the medication and maintained until the umbilical cord is clamped.…”

Section: Transplacental Transmissionmentioning

confidence: 99%

Use of Antirretrovirals in the Gestational Period, Their Impacts and the Prevention of Vertical Transmission of Hiv: Systematic Review

Souza,

Neto,

Doering

et al. 2023

JHS

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Introduction:Antiretroviral therapy (ART) is a right offered by the SUS to all HIV-positive pregnant women, making it efficient in preventing vertical transmission. Objective: search in the literature how the use of therapy can impact the health of the pregnant woman and her unborn child, what are the measures adopted in the country to prevent vertical transmission. Methodology: This is a descriptive study, with retrospective data collection, through a narrative review, through articles and publications found in the SCIELO, LILACS, PubMed, MEDLINE database, institutional publications from the Ministry of Health and articles from Brazilian Society of Infectious Diseases with a temporal scope from 2011 to 2021. Final considerations: It is well known that every drug, regardless of its origin, whether allopathic or herbal, brings adverse reactions to the body. Likewise, antiretrovirals prescribed for the therapy of HIV-positive women during pregnancy can cause undesirable reactions. However, the benefits of ART indisputably outweigh all the side effects arising from antiretrovirals and to date there is no other effective and safe way to prevent the transmission of HIV from mother to child.

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“…Um aumento na CV e níveis de linfócitos CD4 + inferiores a 200/mm³ são os principais responsáveis pela transmissão vertical. 19,20 Sabe-se há muito tempo que as mães que apresentam viremia detectável e status clínico comprometido têm risco de duas a três vezes maior de transmitir a doença ao seu concepto.…”

Section: 23unclassified

Perfil de gestantes em tratamento para a infecção pelo vírus da imunodeficiência humana

Beck

Cauzzo

Vielmo

et al. 2018

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. A média da idade no período da gestação foi de 29 anos (± 5,9), apenas 24% teve o diagnóstico fora de período gestacional, e a maioria (69,6%) sabia ser portadora do HIV antes da gestação atual, sendo que apenas 11,6% estavam esperando o primeiro filho. A maioria das gestantes recebeu TARV por mais de seis meses de gestação (60,9%). O pré-natal não foi realizado adequadamente em 19,6% destas gestantes resultando em TARV insatisfatória. Conclusão: Sendo o HIV uma infecção silenciosa, a gestação torna-se um momento oportuno para diagnóstico desta infecção. É necessária maior sensibilização quanto à importância de um pré-natal precoce e de adesão a TARV, buscando minimizar os riscos da transmissão vertical do HIV. Descritores: Gestantes. HIV. AIDS. Terapia Antiretroviral. Transmissão Vertical de Doença Infecciosa. Background and Objectives:The predominant transmission route in cases of HIV/pediatric aids continues to be vertical transmission. Since HIV infection is a chronic and controllable disease, monitoring the treatment of the mother and her child is fundamental. The objective was to verify the profile of HIV-positive pregnant women attended at a public hospital in the central region of Rio Grande do Sul, and when it was made the diagnosis. Methods: A descriptive, cross-sectional, retrospective study was carried out with 46 pregnant women undergoing antiretroviral treatment (ART) for HIV during the period from January to December 2015. Data were obtained through the consultation in the Logistic Control System of Medications, in the hospital pharmacy, and in the medical records. Results: The mean age of the gestation period was 29 years old (± 5,9). Only 24% had the diagnosis outside the gestational period, and the majority (69,6%) knew to be HIV positive before the current gestation, with only 11, 6% expecting the first child. The majority of pregnant women received ART for more than 6 months of gestation (60.9%). Prenatal care was not adequately performed in 19.6%, and these pregnant women were not adequately treated. Conclusion: Since HIV is a silent infection, gestation becomes an opportune moment for the diagnosis of this infection. However, greater awareness of the importance of early prenatal care and adherence to ART is needed, in order to minimize the risk of vertical transmission of HIV.

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Modeling of In-Utero and Intra-Partum Transmissions to Evaluate the Efficacy of Interventions for the Prevention of Perinatal HIV

Cited by 12 publications

References 29 publications

<p>Prevention of mother-to-child transmission (PMTCT) of HIV: a review of the achievements and challenges in Burkina-Faso</p>

<p>Prevention of mother-to-child transmission (PMTCT) of HIV: a review of the achievements and challenges in Burkina-Faso</p>

Use of Antirretrovirals in the Gestational Period, Their Impacts and the Prevention of Vertical Transmission of Hiv: Systematic Review

Perfil de gestantes em tratamento para a infecção pelo vírus da imunodeficiência humana

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