Modeling of hyperthermia induced by functionalized gold nanorods bound to Staphylococcus aureus under NIR laser radiation

Yakunin, A. N.; Zarkov, Sergey V.; Avetisyan, Yuri A.; Akchurin, Garif G.; Tuchina, Elena S.; Tuchin, Valery V.

doi:10.1117/12.2531440

Cited by 4 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main challenge concerning GNPs‐based thermal therapy consists in the delivery of an optimized concentration of NPs inside the target, sufficient to enhance the thermal effect while reducing laser intensity for sparing the healthy tissue [56]. Indeed, GNPs’ optical properties, shape and size, coating, concentration, in association with laser wavelengths and powers [57–61], and tumor biological and chemical properties impact on the GNPs‐assisted PTT outcomes, as well as on the cell death mechanisms [5,48]. In this framework, also adequate tools for the planning and prediction of the GNPs‐based thermal therapy settings, along with approaches for intraprocedural monitoring of the thermal outcome could provide a valid support for the design and control of the therapy.…”

Section: Introductionmentioning

confidence: 99%

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Asadi

Bianchi

Landro

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

Gold nanoparticles (GNPs)‐based photothermal therapy (PTT) is a promising minimally invasive thermal therapy for the treatment of focal malignancies. Although GNPs‐based PTT has been known for over two decades and GNPs possess unique properties as therapeutic agents, the delivery of a safe and effective therapy is still an open question. This review aims at providing relevant and recent information on the usage of GNPs in combination with the laser to treat cancers, pointing out the practical aspects that bear on the therapy outcome. Emphasis is given to the assessment of the GNPs’ properties and the physical mechanisms underlying the laser‐induced heat generation in GNPs‐loaded tissues. The main techniques available for temperature measurement and the current theoretical simulation approaches predicting the therapeutic outcome are reviewed. Topical challenges in delivering safe thermal dosage are also presented with the aim to discuss the state‐of‐the‐art and the future perspective in the field of GNPs‐mediated PTT.

show abstract

Section: Introductionmentioning

confidence: 99%

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Asadi

Bianchi

Landro

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…локальной температуры в окрестности наночастицы и средней температуры суспензии представлены в работах [27,28]. Этот механизм лежит в основе повреждений, возникающих в клетке, и влечет за собой ее гибель [1][2][3][4][5][6]10,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. В ходе данного исследования показано, что два типа ЗНЧ (нанокубики и наностержни) вызывали дозозависимое сокращение численности бактериальных популяций под действием излучения с мощностью 60 mW/сm 2 .…”

Section: Discussionunclassified

“…Несмотря на то, что нагрев суспензий, содержащих золотые нанокубики и наностержни, происходил не более чем на 5−6 • C, локальный нагрев в точках контакта частиц и клеточных стенок бактерий значительно выше [27,28], что приводит к повреждениям клеток и снижению выживаемости.…”

Section: Discussionunclassified

“…Выраженное подавляющее действия ИК2 с плотностью мощности 400 mW/сm 2 связано, по всей видимости, с механизмами, описанными выше. При этом нанодиски вносят дополнительный вклад в уничтожение бактериальной популяции с очень высокой эффективностью вплоть до 99% в ходе локальных фототермических процессов (сильного перегрева клеток в местах контакта с наночастицами) [27,28] и действия сильных оптических полей, возникающих на наноразмерных неоднородностях нанодисков и приводящих к дополнительной генерации АФК [32][33][34]. С другой стороны, такое излучение приводят к быстрому нагреву исследуемых образцов без наночастиц (на 9 • C) и дополнительно +1.6 • C в присутствии стеклянной подложки с золотыми нанодисками.…”

Section: Discussionunclassified

See 1 more Smart Citation

Фототермическое действие инфракрасного (808 nm) лазерного излучения и наночастиц золота в различных модификациях на S. aureus

Tuchina¹,

Тучин²

2020

Журнал Технической Физики

View full text Add to dashboard Cite

The effect of infrared laser radiation (808 nm) of different fluence rates on the bacteria Staphylococcus aureus 209 P, incubated in solutions of gold nanocubes, nanorods and on glass substrates with fixed nanodiscs, was studied. Radiation with a power density of 60 mW/cm2 in combination with nanocubes caused the death of 50% of the bacterial population after 30 min of exposure, in combination with nanostructures - 56%. An increase in the temperature of suspended matter after irradiation was found of no more than 5-6 °C. Radiation with a power density of 400 mW/cm2 caused a pronounced inhibition of the viability of bacterial cells – by 81% after 30 min. Incubation of microorganism suspensions on the surface of glass substrate containing gold nanodiscs during irradiation (808 nm, 400 mW/cm2) resulted in 99% of bacterial cell death.

show abstract

“…The formation of a local temperature field in suspensions of microorganisms with embedded AuNRs under irradiation with a NIR laser (power density of around 100 mW/cm 2 ) was considered theoretically in Ref. [229]. It was found that AuNPs functionalized by human immunoglobulins IgA and IgG formed "clouds" around cells and induced temperature rise in the microscale zone.…”

Section: Evaluation Of Optical Properties Of Tumors and The Propagati...mentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

Self Cite

View full text Add to dashboard Cite

Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

show abstract

Modeling of hyperthermia induced by functionalized gold nanorods bound to Staphylococcus aureus under NIR laser radiation

Cited by 4 publications

References 26 publications

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Laser‐induced optothermal response of gold nanoparticles: From a physical viewpoint to cancer treatment application

Фототермическое действие инфракрасного (808 nm) лазерного излучения и наночастиц золота в различных модификациях на S. aureus

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Contact Info

Product

Resources

About