Modeling of Diffuse Reflectance Near-infrared Spectroscopy Based System for Noninvasive Tissue Glucose Level Measuring

Litinskaia, Evgeniia L.; Mikhailov, Mikhail O.; Polyakova, Elizaveta A.; Pozhar, K. V.

doi:10.1109/elconrus51938.2021.9396609

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Biochemical assays measure changes in biochemical reactions using reagents sensitive to glucose, 34 and optical methods rely on glucose’s intrinsic molecular properties to determine its levels in tissue fluids. 35 – 40 The main challenge that NI glucose monitoring techniques face is achieving the required accuracy at an affordable cost without using blood samples for measurements. 41 The majority of NI glucose monitoring techniques utilized a single method to monitor physiological changes related to blood glucose levels.…”

Section: Discussionmentioning

confidence: 99%

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels

Kang,

Shen,

Huang

et al. 2024

J. Biomed. Opt.

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Monitoring blood glucose levels is crucial for individuals with diabetes. Noninvasive methods for measuring serum glucose levels have been explored to aid in blood glucose control for diabetes management.Aim: We introduced a noncontact optical glucometer (NCGM) for measuring glucose levels in the aqueous humor of the human eye. We also investigated the correlation between glucose levels in the NCGM and the aqueous humor, blood samples, and self-monitoring blood glucose devices.Approach: The optical system used in this study measured both the near-infrared absorption and polarized rotatory distribution of glucose molecules in the human aqueous humor. This prospective study's outcomes were eye aqueous glucose level, preoperative blood glucose level, intraoperative blood glucose level, and NCGM reading of patients in a single center in Taiwan.Results: The NCGM's measurements showed a strong correlation with blood glucose levels (intra-class correlation [ICC]: 0.95 to 0.98) and aqueous humor glucose levels (ICC: 0.76), indicating its ability to noninvasively measure blood glucose levels in human subjects.Conclusions: This NCGM may offer a convenient, pain-free, and rapid tool for measuring blood glucose levels in diabetic patients. The device could represent a significant advancement in noncontact hybrid optical glucose measurement systems.

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Section: Discussionmentioning

confidence: 99%

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels

Kang,

Shen,

Huang

et al. 2024

J. Biomed. Opt.

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Near Infrared Spectra Data Analysis by Using Machine Learning Algorithms

Xiao

Chen

2022

Lecture Notes in Networks and Systems

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Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

et al. 2021

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The noninvasive measurement of serum glucose levels has been investigated for the monitoring of blood sugar control in diabetes. In our study, we aimed to develop a novel noncontact glucometer (NCGM) utilizing an optical approach to measure the intraocular aqueous humor glucose levels in the anterior chamber of rabbit eyes. The NCGM consists of a hybrid optical system that simultaneously measures near-infrared absorption and the polarized rotatory distribution of glucose molecules in the aqueous humor. In vitro optical measurements demonstrated that NCGM measurements had high precision and repeatability for different glucose levels, including 50 mg/dL (14.36%), 100 mg/dL (−4.05%), 200 mg/dL (−5.99%), 300 mg/dL (4.86%), 400 mg/dL (−2.84%), 500 mg/dL (−0.11%), and 600 mg/dL (4.48%). In the rabbit experiments, we found a high correlation between aqueous glucose levels and serum glucose levels, with a mean difference of 8 mg/dL. According to the testing results, the in vivo NCGM measurement of aqueous humor glucose levels also displayed a high correlation with serum glucose levels, with a mean difference of 29.2 mg/dL. In conclusion, aqueous humor glucose levels were accurately measured using the NCGM, and the results correlated with serum glucose levels.

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Modeling of Diffuse Reflectance Near-infrared Spectroscopy Based System for Noninvasive Tissue Glucose Level Measuring

Cited by 3 publications

References 4 publications

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels

Noncontact optical device for measuring blood glucose in aqueous humor: a pilot clinical study investigating correlation with blood glucose levels

Near Infrared Spectra Data Analysis by Using Machine Learning Algorithms

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit

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