Insulator-based dielectrophoresis is a recently developed technique in which insulating posts are used to produce non-uniformity in the electric eld in a microchannel. This study presents the e ects of insulating posts' geometry and arrangement on the trapping e ciency of red blood cells in an alternating current-insulator-based dielectrophoresis system. Microchannels containing square, circular, and diamond-shaped posts with particles under the in uence of positive dielectrophoresis force and uid ow were considered in this study. The nite element method was used to compute the velocity of the ow and electric eld. The numerical method was veri ed by comparing the numerical results with experimental data. Two distinct criteria for examining particle trapping for distinct shapes and arrangements of insulating posts were introduced. Particle tracing simulation was implemented to observe particle trapping and compare the trapping performance of systems with distinct posts. As shown in the results for the system with circular and square posts, insulators should be narrowed to improve particle trapping, while the diamond post should be widened to increase the trapping e ciency. In addition, the particle tracking results showed that the microchannel with square posts was more e cient in particle trapping.