Modeling of contact theories for the manipulation of biological micro/nanoparticles in the form of circular crowned rollers based on the atomic force microscope

Korayem, Moharam Habibnejad; Khaksar, H.; Taheri, M.

doi:10.1063/1.4829919

Cited by 17 publications

(10 citation statements)

References 26 publications

(21 reference statements)

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“…To compare the elastic properties' differences between cancer cells and their counterpart normal cells, the relative Young's modulus ( ) is defined as follows: R = cancer cell / counterpart normal cell (10) where cancer cell and counterpart normal cell are Young's moduli of the cancerous and normal cells, respectively. The results of this paper show that the relative Young's modulus is about 0.75 which shows the softness of cancer cell in comparison with a normal one.…”

Section: Comparison Between the Cancerous And Healthy Breast Cells' Rmentioning

confidence: 99%

“…There are various devices hired to measure biological cell's different properties, one of which is atomic force microscopy (AFM) [16]. The advantage of AFM over other methods is its capability to present information about other properties such as adhesion distribution, friction, elasticity module, viscoelastic characteristics and surface topography [10]. AFM function in the case of soft surfaces, such as cells and polymers, has some complexities; Weisenhorn et al obtained force-distance and force-indentation depth curves for elastomers, rubbers and biological cells in contact moments and extracted the parabolic curves.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Characterization of MCF-10A Normal Cells Using AFM: Comparison with MCF-7 Cancer Cells

Korayem¹,

Rastegar²

2019

Molecular &Amp; Cellular Biomechanics

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The mechanical properties of single cells have been recently identified as the basis of an emerging approach in medical applications since they are closely related to the biological processes of cells and human health conditions. The problem in hand is how to measure mechanical properties in order to obtain them more accurately and applicably. Some of the cell's properties such as elasticity module and adhesion have been measured before using various methods; nevertheless, comprehensive tests for two healthy and cancerous cells have not been performed simultaneously. As a Nanoscale device, AFM has been used for some biological cells, however for breast cells, it has been utilized just to measure elasticity module. To provide a more accurate comparison for the healthy and the malignant cancer cells of breast, mechanical properties of MCF-10A cells such as topography, elasticity module, adhesion force, viscoelastic characteristics, bending and axial rigidity were determined and compared to the MCF-7 cells results obtained in previous works. Results revealed that the healthy breast cells are stiffer and less adhesive in comparison with the cancerous ones. Topography images revealed that cancerous cells have bigger radii. These results can help with the diagnosis of malignant cancer cells and even the level of the disease.

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Section: Comparison Between the Cancerous And Healthy Breast Cells' Rmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental Characterization of MCF-10A Normal Cells Using AFM: Comparison with MCF-7 Cancer Cells

Korayem¹,

Rastegar²

2019

Molecular &Amp; Cellular Biomechanics

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“…Therefore, to simulate this biological cell at contact moment, a spherical bundle of DNA has been considered. Also, assuming DNA molecule to be cylindrical or circular capped cylinder, Korayem et al [16] compared the contact mechanics of these two geometries with the results obtained from the spherical geometry, and concluded that the indentation depth created in the spherical geometry is greater than that produced in the other two types of geometries.…”

Section: Elasto-plastic Impact Theory Of Andrewsmentioning

confidence: 99%

Simulating the impact between particles with applications in nanotechnology fields (identification of properties and manipulation)

2014

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The aim of this research is to study and simulate the Andrews impact theory and its potential in identifying the properties of soft biological particles and in manipulating these particles at nano scale by means of the atomic force microscope (AFM). The reason for employing the Andrews theory in this research is that this theory is unique in considering the plastic state of soft biological nanoparticles. First, the required equations for the estimation of two basic parameters (i.e., indentation depth and contact radius) used in the identification of properties and manipulation of these particles were derived. Since none of the previous works has considered the velocity of biological nanoparticles, and since the impact of biological particles with AFM tip and with substrate has been ignored in these works, the impacts between AFM tip and DNA particle and between DNA particle and substrate were simulated in this paper. The findings showed that before applying a load to a particle by a cantilever, due to the impact of AFM tip with the particle, a relatively noticeable deformation was created. This deformation, which has been disregarded in previous works up to now, can play an important role in identifying the properties of nanoparticles, in manipulation and even in controlling the cantilever of the atomic force microscope. The existing experimental results were used to validate the findings of this research.

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“…Korayem et al developed and modeled a number of contact theories for biological nanoparticles shaped as cylinders and circular crowned rollers for application in the manipulation of different biological micro/nanoparticles using AFM. They adapted the contact theory in accordance with the geometry of the particles to the extracted force-displacement curve via AFM and calculated the critical time and force in the manipulation using the indentation depth and contact radius [14].…”

Section: Introductionmentioning

confidence: 99%

The head and neck cancer (HN-5) cell line properties extraction by AFM

2020

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This work incorporates experimental methods based on Atomic Force Microscopy (AFM) in order to extract the physical and mechanical characteristics of the head and neck cancer (HN-5) cell line such as cell topography, modulus of elasticity and viscoelastic properties. The initial parameters to determine the mechanical properties are obtained by extracting information from cantilever's force-displacement curve and vertical and horizontal displacement. Next, the changes in elasticity modulus at different points in the cell are attained using the experimental results, followed by studying the differences of these properties at various spots of the cell. Furthermore, cellular folding factor is calculated as a significant property in diagnosing the extent of cancer progression. Moreover, parameters such as adhesion and intermolecular forces are measured which are involved in the first phase of manipulation and during the application of the cantilever force to the particle. Finally, after calculating the indentation depth and contact radius using contact theories, critical manipulation time and force are obtained. Through modeling the cell, the creep function, the spring constant and the damping coefficient corresponding to the cell, are also extracted.

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Modeling of contact theories for the manipulation of biological micro/nanoparticles in the form of circular crowned rollers based on the atomic force microscope

Cited by 17 publications

References 26 publications

Experimental Characterization of MCF-10A Normal Cells Using AFM: Comparison with MCF-7 Cancer Cells

Experimental Characterization of MCF-10A Normal Cells Using AFM: Comparison with MCF-7 Cancer Cells

Simulating the impact between particles with applications in nanotechnology fields (identification of properties and manipulation)

The head and neck cancer (HN-5) cell line properties extraction by AFM

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