Modeling of blood flow in the human aorta with use of an orthotropic nonlinear material model for the walls

Kojić, Miloš; Filipović, Nenad; Vlastelica, Ivo; Živković, Miroslav

doi:10.1016/b978-008044046-0.50427-9

Cited by 1 publication

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The channel geometries and initial RBC positions were then input into our custom-built finite-element software package PAK 49 and run on a desktop supercomputer consisting of 32 cores (Supermicro Super Server: 4× Eight-Core Intel Xeon Processor 2.70 GHz; 512 GB total memory). Biophysical modeling of chemoattractant diffusion in the device was performed using COMSOL Multiphysics software.…”

Section: Methodsmentioning

confidence: 99%

Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood

et al. 2013

View full text Add to dashboard Cite

Neutrophil chemotaxis is critical for defense against infections and its alterations could lead to chronic inflammation and tissue injury. The central role that transient alterations of neutrophil chemotaxis could have on patient outcomes calls for its quantification in the clinic. However, current methods for measuring neutrophil chemotaxis require large volumes of blood and are time consuming. To address the need for rapid and robust assays, we designed a microfluidic device that measures neutrophil chemotaxis directly from a single droplet of blood. We validated the assay by comparing neutrophil chemotaxis from finger prick, venous blood and purified neutrophil samples. We found consistent average velocity of (19 ± 6 μm/min) and directionality (91.1%) between the three sources. We quantified the variability in neutrophil chemotaxis between healthy donors and found no significant changes over time. We also validated the device in the clinic and documented temporary chemotaxis deficiencies after burn injuries.

show abstract

Section: Methodsmentioning

confidence: 99%