Modeling of ayurveda ghee based solid lipid nano particles and their comprehensive pharmacokinetics study

Venkidasamy, Baskar; Lakshmi, B. Jyothi; Ibrahim, Kh. M.; Shabeer, T K; Ali, Akhtar

doi:10.1016/j.matpr.2020.07.002

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Lipid nanoparticle can be prepared by various methods, such as high-pressure homogenization, solvent diffusion, microemulsion template, solvent injection, ultrasonication, solvent emulsification, reverse micelles double emulsion, cold homogenization, and membrane contactor methods (Baskar et al, 2021). SLN is one of the efficient delivery systems for bioactive compounds.…”

Section: Lipid Nanoparticlesmentioning

confidence: 99%

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

Choudhary

Dutta²,

Moses³

et al. 2023

Qual. Assur. Saf. Crops Foods

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α-lipoic acid (LA) is a potent antioxidant available in various plant and animal sources. Of late, there is high market demand for LA-based nutraceuticals, owing to enhanced occurrences of oxidative stress-based diseases. However, the effectiveness of LA is challenged with its low solubility, less stability, and low bioavailability. In addition, the unpleasant taste of LA limits its applications in food systems. In this context, encapsulation techniques can modify the chemical and biological properties of LA and improve its solubility and stability in the aqueous medium, which in turn helps in the development of different innovative therapeutic products based on LA. Different encapsulation techniques such as inclusion complexes, spray drying, electrospraying, solid lipid nanoparticles (SLN), emulsification, and liposomes have been explored for the encapsulation of LA. This review focuses on the biological activities of LA in terms of antioxidant, antidiabetic, anticancer, and anti-inflammatory properties, and the scope of encapsulation to enhance these properties, as evidenced through in vitro and in vivo studies. Furthermore, this article will help researchers and industrialists to select the suitable encapsulation method based on their requirement for delivering LA to achieve its optimal therapeutic potential.

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Section: Lipid Nanoparticlesmentioning

confidence: 99%

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

Choudhary

Dutta²,

Moses³

et al. 2023

Qual. Assur. Saf. Crops Foods

View full text Add to dashboard Cite

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Lipid Nanoparticulate Drug Delivery Systems: Approaches toward Improvement in Therapeutic Efficacy of Bioactive Molecules

Singh¹,

Dodiya²,

Dodiya³

et al. 2022

Drug Carriers

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Hybrid lipid polymers significantly changed the postulation of low or less bioavailability of conventional drug delivery systems. Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs with enhanced therapeutic efficacy and are well described in the scientific literature. Among these, lipid polymer-based nanoparticles have specifically come up for dermal, transdermal, mucosal, intramuscular, and ocular drug administration routes in the last 20 years. Moreover, lipid nanoparticles showed potential for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. Therefore, the multifarious nanostructured lipid carriers can reduce the undesired effects with maximum utilization of active moiety. In this, chapter a brief discussion is presented on the source of synthetic and natural lipid polymers with the use of surfactants. Moreover, a summary on formulation and pharmaceutical characterization of nanostructured lipid carriers considering solid lipid nanoparticles and vesicular drug delivery systems has been taken into consideration. In addition, a light on bioactive fortified with lipid nanoparticles was reviewed for maximizing its therapeutic efficacy. Furthermore, this chapter’s focus to bring out the latest applications via recent scientific publications from the Scopus database on nanostructure carriers that showed promising application for the treatments of potentially life-threatening diseases has been summarized.

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Modeling of ayurveda ghee based solid lipid nano particles and their comprehensive pharmacokinetics study

Cited by 2 publications

References 14 publications

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

Lipid Nanoparticulate Drug Delivery Systems: Approaches toward Improvement in Therapeutic Efficacy of Bioactive Molecules

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