Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

Sawaftah, Nour Al; Paul, Vinod K.; Awad, Nahid S.; Husseini, Ghaleb A.

doi:10.1109/tnb.2021.3097909

Cited by 23 publications

(31 citation statements)

References 80 publications

(97 reference statements)

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“…The dissolution ratios of POC-x elastomers were fast first, then slow, and finally stabilized, which was similar to their water absorption (Figure c). According to relevant literature reported, the behavior was classified as the solvent-controlled release. ,− The release mode of many drugs was based on this strategy. ,, Here, water-soluble components mainly coming from the interior of POC-x samples were released, which was driven by osmotic pressure and water as the carrier. The key point was water diffusion, namely, water absorbability.…”

Section: Resultsmentioning

confidence: 99%

“…25,35−37 The release mode of many drugs was based on this strategy. 29,36,38 Here, water-soluble components mainly coming from the interior of POC-x samples were released, which was driven by osmotic pressure and water as the carrier. The key point was water diffusion, namely, water absorbability.…”

Section: Surface Hydrophilicity and Water Absorbability Investigation...mentioning

confidence: 99%

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Bulk Erosion Degradation Mechanism for Poly(1,8-octanediol-co-citrate) Elastomer: An In Vivo and In Vitro Investigation

Wan

Zhu

et al. 2022

Biomacromolecules

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As a biodegradable elastomer, poly(1,8-octanediolco-citrate) (POC) has been widely applied in tissue engineering and implantable electronics. However, the unclear degradation mechanism has posed a great challenge for the better application and development of POC. To reveal the degradation mechanism, here, we present a systematic investigation into in vivo and in vitro degradation behaviors of POC. Initially, critical factors, including chemical structures, hydrophilic and water-absorbency characteristics, and degradation reaction of POC, are investigated. Then, various degradation-induced changes during in vitro degradation of POC-x (POC with different cross-linking densities) are monitored and discussed. The results show that (1) cross-linking densities exponentially drop with degradation time; (2) mass loss and PBSabsorption ratio grow nonlinearly; (3) the morphology on the cross-section changes from flat to rough at a microscopic level; (4) the cubic samples keep swelling until they collapse into fragments from a macro view; and (5) the mechanical properties experience a sharp drop at the beginning of degradation. Finally, the in vivo degradation behaviors of POC-x are investigated, and the results are similar to those in vitro. The comprehensive assessment suggests that the in vitro and in vivo degradation of POC occurs primarily through bulk erosion. Inflammation responses triggered by the degradation of POC-x are comparable to poly(lactic acid), or even less obvious. In addition, the mechanical evaluation of POC in the simulated application environment is first proposed and conducted in this work for a more appropriate application. The degradation mechanism of POC revealed will greatly promote the further development and application of POC-based materials in the biomedical field.

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Section: Resultsmentioning

confidence: 99%

Section: Surface Hydrophilicity and Water Absorbability Investigation...mentioning

confidence: 99%

Bulk Erosion Degradation Mechanism for Poly(1,8-octanediol-co-citrate) Elastomer: An In Vivo and In Vitro Investigation

Wan

Zhu

et al. 2022

Biomacromolecules

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“…First-order release model is fit for the diffusion curve of BBHloaded liposomes-gel in vitro, and the results are shown in Figure 5. According to curve fitting, the release of BBH from the liposomes-gel followed a first-order release model, 23 and the correlation R 2 is above 0.99 (Table 4).…”

Section: In Vitro Release Studymentioning

confidence: 99%

Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity

Wang¹,

Xia²,

Xia³

et al. 2023

Ind. J. Pharm. Edu. Res

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Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine hydrochloride has been hindered for a long time due to its poor solubility and low bioavailability. This study aims to design a liposomes-gel to enhance the bioavailability and antioxidant activity of berberine hydrochloride. Materials and Methods:The thin-film dispersion hydration method was used to prepare liposomes, and liposomes-gel was prepared by the natural swelling method using sodium alginate as the hydrogel matrix. Berberine hydrochloride-loaded liposomes-gel was characterized by the encapsulation efficiency, particle size, potential, and transmission electron microscopy, and studied by in vitro release and antioxidant activity of the preparations. Results: The results revealed the encapsulation efficiency of berberine hydrochloride-loaded liposomes was 79.62±4.20% and the mean particle size was 153.7±11.2 nm. The release of berberine hydrochloride from liposomes-gel conformed to a first-order release model. The scavenging rate of DPPH free radicals and H 2 O 2 by berberine hydrochloride-loaded liposomes-gel exceeds 70%. Conclusion:The liposomes-gel has a sustained-release effect on berberine hydrochloride. Berberine hydrochloride-loaded liposomes-gel had good antioxidant properties by measuring the scavenging ability on DPPH free radicals, H 2 O 2 and lipid peroxidation resistance.

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“…Here, k depends on the structural characteristics of the liposome and the drug, and n is the parameter relative to the drug release mechanism (Fickian diffusion or non-Fickian diffusion) and carrier geometry. At the same time, other models can be investigated to predict the release of a drug from biologically targeted nanocarriers [ 182 , 183 , 184 , 185 , 186 ].…”

Section: Limitation Of the Reviewmentioning

confidence: 99%

Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools

Kutumova

Akberdin

Kiselev

et al. 2022

IJMS

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Cancer treatment and pharmaceutical development require targeted treatment and less toxic therapeutic intervention to achieve real progress against this disease. In this scenario, nanomedicine emerged as a reliable tool to improve drug pharmacokinetics and to translate to the clinical biologics based on large molecules. However, the ability of our body to recognize foreign objects together with carrier transport heterogeneity derived from the combination of particle physical and chemical properties, payload and surface modification, make the designing of effective carriers very difficult. In this scenario, physiologically based pharmacokinetic modeling can help to design the particles and eventually predict their ability to reach the target and treat the tumor. This effort is performed by scientists with specific expertise and skills and familiarity with artificial intelligence tools such as advanced software that are not usually in the “cords” of traditional medical or material researchers. The goal of this review was to highlight the advantages that computational modeling could provide to nanomedicine and bring together scientists with different background by portraying in the most simple way the work of computational developers through the description of the tools that they use to predict nanoparticle transport and tumor targeting in our body.

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Modeling of Anti-Cancer Drug Release Kinetics From Liposomes and Micelles: A Review

Cited by 23 publications

References 80 publications

Bulk Erosion Degradation Mechanism for Poly(1,8-octanediol-co-citrate) Elastomer: An In Vivo and In Vitro Investigation

Bulk Erosion Degradation Mechanism for Poly(1,8-octanediol-co-citrate) Elastomer: An In Vivo and In Vitro Investigation

Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity

Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools

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