Modeling NK-cell lymphoma in mice reveals its cell-of-origin and microenvironmental changes and identifies therapeutic targets
Junji Koya,
Tomohiko Tanigawa,
Kota Mizuno
et al.
Abstract:Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm preferentially involving the upper aerodigestive tract. Here we show that NK-cell-specific
Trp53
disruption in mice leads to the development of NK-cell lymphomas after long latency, which involve not only the hematopoietic system but also the salivary glands. Before tumor onset,
Trp53
knockout causes extensive gene expression changes, resulting in immature NK-cell expansion, excl… Show more
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