This paper presents a tunable effective-one-body (EOB) model for black-hole (BH) binaries of arbitrary mass-ratio and aligned spins. This new EOB model incorporates recent results of smallmass-ratio simulations based on Teukolsky's perturbative formalism. The free parameters of the model are calibrated to numerical-relativity simulations of non-spinning BH-BH systems of five different mass-ratios and to equal-mass non-precessing BH-BH systems with dimensionless BH spins χi ≃ ±0.44. The present analysis focuses on the orbital dynamics of the resulting EOB model, and on the dominant (ℓ,m)=(2,2) gravitational-wave mode. The calibrated EOB model can generate inspiral-merger-ringdown waveforms for non-precessing, spinning BH binaries with any mass ratio and with individual BH spins −1 ≤ χi 0.7. Extremizing only over time and phase shifts, the calibrated EOB model has overlaps larger than 0.997 with each of the seven numerical-relativity waveforms for total masses between 20M⊙ and 200M⊙, using the Advanced LIGO noise curve. We compare the calibrated EOB model with two additional equal-mass highly spinning (χi ≃ −0.95, +0.97) numerical-relativity waveforms, which were not used during calibration. We find that the calibrated model has overlap larger than 0.995 with the simulation with nearly extremal anti-aligned spins. Extension of this model to black holes with aligned spins χi 0.7 requires improvements of our modeling of the plunge dynamics and inclusion of higher-order PN spin terms in the gravitational-wave modes and radiation-reaction force.