Modeling metastatic progression from cross-sectional cancer genomics data
Kevin Rupp,
Andreas Lösch,
Yanren Linda Hu
et al.
Abstract:Motivation
Metastasis formation is a hallmark of cancer lethality. Yet, metastases are generally unobservable during their early stages of dissemination and spread to distant organs. Genomic datasets of matched primary tumors and metastases may offer insights into the underpinnings and the dynamics of metastasis formation.
Results
We present metMHN, a cancer progression model designed to deduce the joint progression of primar… Show more
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