Modeling Mesenchymal Stem Cells in TMJ Rheumatoid Arthritis and Osteoarthritis Therapy

Serakıncı, Nedime; Savtekin, Gokce

doi:10.1615/critreveukaryotgeneexpr.2017019380

Cited by 7 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the development of tissue engineering strategies represents a booming field of research, achieving the restoration of degraded cartilage and subchondral bone lesions. An emerging role of stem cells in TMD has been highlighted for their ability to regenerate TMJ, including mesenchymal stem cells in the progressive degeneration of articular disc displacement [126][127][128]. Mesenchymal stem cells are multipotent stem cells assigned to repair skeletal tissues such as cartilage, bone, and bone marrow and could represent a valid alternative in TMJOA, as supported by several studies [126][127][128].…”

Section: Alternative Therapies For Tmd Managementmentioning

confidence: 98%

Polyphenols as Potential Agents in the Management of Temporomandibular Disorders

et al. 2020

View full text Add to dashboard Cite

Temporomandibular disorders (TMD) consist of multifactorial musculoskeletal disorders associated with the muscles of mastication, temporomandibular joint (TMJ), and annexed structures. This clinical condition is characterized by temporomandibular pain, restricted mandibular movement, and TMJ synovial inflammation, resulting in reduced quality of life of affected people. Commonly, TMD management aims to reduce pain and inflammation by using pharmacologic therapies that show efficacy in pain relief but their long-term use is frequently associated with adverse effects. For this reason, the use of natural compounds as an effective alternative to conventional drugs appears extremely interesting. Indeed, polyphenols could represent a potential therapeutic strategy, related to their ability to modulate the inflammatory responses involved in TMD. The present work reviews the mechanisms underlying inflammation-related TMD, highlighting the potential role of polyphenols as a promising approach to develop innovative management of temporomandibular diseases.

show abstract

Section: Alternative Therapies For Tmd Managementmentioning

confidence: 98%

Polyphenols as Potential Agents in the Management of Temporomandibular Disorders

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The direct injection of human mesenchymal cells into arthritic joints showed better articular cartilage repair and slowing down of the arthritic progression. 76 However, there is still a need to produce cartilage discs in the presence of advanced destruction, and many approaches have also utilized scaffolds loaded with cells. Nasal chondrocytes extracted from nasal cartilage of adult female white rabbits were reported to successfully treat a knee articular disc defect in an adult rabbit model when used with an injectable hydrogel scaffold.…”

Section: Cartilagementioning

confidence: 99%

Recent update on craniofacial tissue engineering

Emara

Shah²

2021

J Tissue Eng

View full text Add to dashboard Cite

The craniofacial region consists of several different tissue types. These tissues are quite commonly affected by traumatic/pathologic tissue loss which has so far been traditionally treated by grafting procedures. With the complications and drawbacks of grafting procedures, the emerging field of regenerative medicine has proved potential. Tissue engineering advancements and the application in the craniofacial region is quickly gaining momentum although most research is still at early in vitro/in vivo stages. We aim to provide an overview on where research stands now in tissue engineering of craniofacial tissue; namely bone, cartilage muscle, skin, periodontal ligament, and mucosa. Abstracts and full-text English articles discussing techniques used for tissue engineering/regeneration of these tissue types were summarized in this article. The future perspectives and how current technological advancements and different material applications are enhancing tissue engineering procedures are also highlighted. Clinically, patients with craniofacial defects need hybrid reconstruction techniques to overcome the complexity of these defects. Cost-effectiveness and cost-efficiency are also required in such defects. The results of the studies covered in this review confirm the potential of craniofacial tissue engineering strategies as an alternative to avoid the problems of currently employed techniques. Furthermore, 3D printing advances may allow for fabrication of patient-specific tissue engineered constructs which should improve post-operative esthetic results of reconstruction. There are on the other hand still many challenges that clearly require further research in order to catch up with engineering of other parts of the human body.

show abstract

“…Damage to TMJ structures is usually irreversible, and commonly used treatment strategies described above cannot restore damaged TMJ tissues. Stem cell‐based therapy is sought as an alternative approach to current treatment strategies, according to few recent studies, to repair discal or bony damage from common conditions such as rheumatoid arthritis and osteoarthritis (Cui et al., 2017; Serakinci & Savtekin, 2017). Two main types of stem cells exist: omnipotent embryonic and non‐embryonic/adult stem cells (Helgeland et al., 2018), which include hematopoietic and mesenchymal stem cells (MSCs), along with neural, epithelial and skin stem cells.…”

Section: Introductionmentioning

confidence: 99%

“…(2014). However, because exogenous MSC injection showed low grafting efficiency, high risk of infection, and the possibility of neoplastic transformation, human clinical trials with stem cells are limited (Cui et al., 2017; Serakinci & Savtekin, 2017). We reviewed current literature regarding human stem cell based TMJ regeneration to assess the efficacy of stem cells for TMJ regeneration/repair in vitro and to explain the necessity for further research for better patient care.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that human MSCs can promote TMJ tissue damage repair, suppress the inflammatory response, and modulate the immune system (El Qashty et al, 2018). Transplanted MSCs can seed in the target tissue or migrate to the target tissue and differentiate into mature cells to help in tissue repair (Cui et al, 2017;Serakinci & Savtekin, 2017). These cells also possess antiinflammatory and immunomodulatory properties, which can speed up the healing process in the TMJ (van Poll et al, 2008).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Regeneration of temporomandibular joint using in vitro human stem cells: A review

Gong

Emperumal

Al‐Eryani

et al. 2022

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Temporomandibular joint disorders (TMDs) range from gross anatomic deformities of the disc and hard tissue to functional disturbances. Traditional treatment of TMDs includes physical therapy, use of appliances, pharmacological, surgical and psychological interventions. However, during the late stage of TMDs, conventional management often results in inadequate relief of symptoms. Stem cell-based tissue regeneration has been studied extensively in joint regeneration, including the Temporomandibular Joint (TMJ). This study aims to review the potential of various human stem cells (HSC) for the regeneration of the TMJ. In vitro studies using human mesenchymal stem cells cultured under different conditions to evaluate regeneration of TMJ related structures were searched on PubMed, EMBASE, Cochrane, and Web of Science up to March 2020. In vitro studies utilized several different types of stem cells under varying conditions. Increased osteogenesis and/ or chondrogenesis were noted with stem cell interventions compared to control groups on Alkaline Phosphatase (ALP) activity, Col-I, Col-II, Col-X, RUNX2, LPL, and Aggrecan mRNA expression. This review emphasizes the potential of stem cell therapies in the regeneration of TMJ-related structures. However, further in vivo studies are required to evaluate the efficacy and safety of these therapies in humans. K E Y W O R D S in vitro, mesenchymal stem cells, review, stem cell therapies, temporomandibular disorders, temporomandibular joint 1 | INTRODUCTION The temporomandibular joint (TMJ) is a complex synovial joint with a unique articulation between the temporal glenoid fossa and the mandibular condyle, which are separated by an articular disc composed of avascular and non-innervated dense fibrous connective tissue with a varying amount of fibrocartilage. The articular disc divides the TMJ cavity into upper and lower chambers. Gliding movement occurs in the upper chamber during the maximal mouth opening, while the lower chamber function primarily as a hinge or rotary movement in the early opening. Because the TMJ has a hinge and sliding movable socket, it is classified as ginglymoarthrodial a joint. The TMJ is surrounded by a fibrous connective tissue capsule attached to muscles and tendons. The capsule is lined by a synovium This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Modeling Mesenchymal Stem Cells in TMJ Rheumatoid Arthritis and Osteoarthritis Therapy

Cited by 7 publications

References 21 publications

Polyphenols as Potential Agents in the Management of Temporomandibular Disorders

Polyphenols as Potential Agents in the Management of Temporomandibular Disorders

Recent update on craniofacial tissue engineering

Regeneration of temporomandibular joint using in vitro human stem cells: A review

Contact Info

Product

Resources

About