2023
DOI: 10.1002/bit.28635
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Modeling large‐scale bioreactors with diffusion equations. Part II: Characterizing substrate, oxygen, temperature, carbon dioxide, and pH profiles

Pauli Losoi,
Jukka Konttinen,
Ville Santala

Abstract: Large‐scale fermentation processes involve complex dynamic interactions between mixing, reaction, mass transfer, and the suspended biomass. Empirical correlations or case‐specific computational simulations are usually used to predict and estimate the performance of large‐scale bioreactors based on data acquired at bench scale. In this two‐part‐study, one‐dimensional axial diffusion equations were studied as a general and predictive model of large‐scale bioreactors. This second part focused on typical fed‐batch… Show more

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Cited by 2 publications
(4 citation statements)
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“…The change in the carbon dioxide concentration in the bioreactor is calculated in the same way as for the oxygen concentration. It is known from the literature that the volumetric mass transfer coefficient for CO 2 is approximately 11% lower than that for oxygen normald c normalC O 2 normald t = 0.89 · k L a · ( c normalC O 2 * c C normalO 2 ) + r normalO 2 c C normalO 2 * = p C normalO 2 H m i x …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The change in the carbon dioxide concentration in the bioreactor is calculated in the same way as for the oxygen concentration. It is known from the literature that the volumetric mass transfer coefficient for CO 2 is approximately 11% lower than that for oxygen normald c normalC O 2 normald t = 0.89 · k L a · ( c normalC O 2 * c C normalO 2 ) + r normalO 2 c C normalO 2 * = p C normalO 2 H m i x …”
Section: Methodsmentioning
confidence: 99%
“…It is known from the literature that the volumetric mass transfer coefficient for CO 2 is approximately 11% lower than that for oxygen. 118 The change in pH due to the formation of CO 2 and the addition of base is calculated using the Henderson− Hasselbalch equation 119…”
mentioning
confidence: 99%
“…The literature correlations that were used in calculating the dispersion coefficient and thus the mixing times are compiled in Table 3 along with their uncertainties. The following dispersion coefficient calculation method is used also in Part II of this study for characterization of substrate, temperature, dissolved oxygen, and pH profiles in large-scale bioreactors (Losoi et al, 2023).…”
Section: Axial Dispersion Coefficientmentioning
confidence: 99%
“…The model's theoretical predictions were also studied and compared to the collected literature data, and various mixing time measurement techniques were interpreted and unified in the context of the diffusion equation. In Part II of this study (Losoi et al, 2023), the focus is on 1D steady-state diffusion equations with first-and zeroth-order kinetics, which were developed to predict and characterize the potentially heterogeneous profiles of substrate, pH, oxygen, and temperature in large-scale stirred bioreactors.…”
Section: Introductionmentioning
confidence: 99%